Thaler M M, Pelger A
Pediatr Res. 1977 Mar;11(3 Pt 1):171-4. doi: 10.1203/00006450-197703000-00005.
Infusions and injections of Intralipid were administered to congenitally jaundiced rats (Gunn) in whom the total body bilirubin pool was uniformly labeled with radioactive bilirubin. These isotopic studies indicated that Intralipid treatment had no effect on the kinetics of bilirubin formation, transport, tissue distribution, and clearance. There were no significant differences between control and fat emulsion-treated animals in the total bilirubin pool, plasma bilirubin pool, biologic half-life of bilirubin, fractional turnover, and exponential decline in plasma bilirubin specific activity at steady state. Bilirubin concentrations in blood, plasma, liver, kidneys, brain, adipose tissue, and muscle were unaltered during the course of continuous infusions (up to 24 hr) of Intralipid. These results indicate that Intralipid administered in clinically applicable doses and regimens has no discernible effects on bilirubin metabolism in jaundiced rats.
将脂肪乳剂输注和注射到先天性黄疸大鼠（Gunn大鼠）体内，这些大鼠的全身胆红素池已用放射性胆红素均匀标记。这些同位素研究表明，脂肪乳剂治疗对胆红素的形成、转运、组织分布和清除动力学没有影响。在总胆红素池、血浆胆红素池、胆红素的生物半衰期、分数周转率以及稳态时血浆胆红素比活性的指数下降方面，对照动物和脂肪乳剂治疗的动物之间没有显著差异。在持续输注（长达24小时）脂肪乳剂的过程中，血液、血浆、肝脏、肾脏、大脑、脂肪组织和肌肉中的胆红素浓度没有改变。这些结果表明，以临床适用剂量和方案给予的脂肪乳剂对黄疸大鼠的胆红素代谢没有明显影响。
