人体对局部尿酸盐晶体诱导炎症的全身反应：一种研究急性期反应的可能模型。
Systemic response to local urate crystal induced inflammation in man: a possible model to study the acute phase response.
作者信息
Hutton C W, Collins A J, Chambers R E, Whicher J, Dieppe P A
出版信息
Ann Rheum Dis. 1985 Aug;44(8):533-6. doi: 10.1136/ard.44.8.533.
Abstract
The production of a systemic inflammatory response to intradermal monosodium urate crystal injection is described. A transient, self-limiting local response is associated with a systemic response detectable by a rise in the white cell count and serum amyloid A protein. The white cell change parallels the evolution of the local response, whereas the serum amyloid A response lags behind the local lesion, peaking after the local lesion is resolving. Intradermal monosodium urate injection is proposed as a possible inflammatory stimulus to explore the acute phase protein response in different disease states.
摘要
本文描述了对皮内注射尿酸钠晶体产生全身炎症反应的情况。短暂的、自限性的局部反应与可通过白细胞计数和血清淀粉样蛋白A蛋白升高检测到的全身反应相关。白细胞变化与局部反应的演变平行，而血清淀粉样蛋白A反应滞后于局部病变，在局部病变消退后达到峰值。皮内注射尿酸钠被提议作为一种可能的炎症刺激物，用于探索不同疾病状态下的急性期蛋白反应。
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