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耳部痛风石:罕见部位的罕见表现。

Auricular Gouty Tophi: A Rare Presentation in an Uncommon Site.

作者信息

Kuang Joo Lee, Abd Mutalib Nor Shahida, Abu Backer Farveen Marican, Abdull Rasid Nurul Syeha, Samsuri Hawairy, Hashim Noor Dina

机构信息

Otorhinolaryngology - Head and Neck Surgery, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MYS.

Otorhinolaryngology - Head and Neck Surgery, Hospital Sultan Abdul Halim, Sungai Petani, MYS.

出版信息

Cureus. 2025 Mar 23;17(3):e81035. doi: 10.7759/cureus.81035. eCollection 2025 Mar.

DOI:10.7759/cureus.81035
PMID:40264604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12013853/
Abstract

Unlike the intense redness and painful swollen joint seen in acute gouty arthritis, classically affecting the first metatarsophalangeal joint called podagra, painless gouty tophi nodules can be found in any soft tissue throughout the body. While they frequently affect areas like the toes, fingers, and olecranon bursae, it is rare to see monosodium urate crystal deposits in the facial region, particularly the ear. This case highlights a patient with uncontrolled hyperuricemia, presenting with an uncommon manifestation of gouty tophi on the auricle. The diagnosis of auricular gouty tophi should be the primary consideration in patients with a nodular auricular mass, whitish material, uncontrolled hyperuricemia, and multiple gouty tophi. Although clinical history, examination findings, and biochemical investigations provide important diagnostic clues, definitive confirmation necessitates surgical excision and histopathological analysis.

摘要

与急性痛风性关节炎中出现的强烈发红和疼痛肿胀的关节不同,典型地影响称为足痛风的第一跖趾关节,无痛性痛风石结节可在全身任何软组织中发现。虽然它们经常影响脚趾、手指和鹰嘴滑囊等部位,但在面部区域,特别是耳部,很少见到尿酸钠晶体沉积。本病例突出了一名高尿酸血症控制不佳的患者,其耳廓出现了痛风石这一罕见表现。对于有耳廓结节性肿物、白色物质、高尿酸血症控制不佳和多发痛风石的患者,应首先考虑耳廓痛风石的诊断。虽然临床病史、检查结果和生化检查提供了重要的诊断线索,但明确诊断需要手术切除和组织病理学分析。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b6a/12013853/44b77dd03883/cureus-0017-00000081035-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b6a/12013853/6fdaab05811a/cureus-0017-00000081035-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b6a/12013853/6149a4d75c99/cureus-0017-00000081035-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b6a/12013853/e44898db49e9/cureus-0017-00000081035-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b6a/12013853/3262a97285d7/cureus-0017-00000081035-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b6a/12013853/1921121cb68c/cureus-0017-00000081035-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b6a/12013853/44b77dd03883/cureus-0017-00000081035-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b6a/12013853/6fdaab05811a/cureus-0017-00000081035-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b6a/12013853/6149a4d75c99/cureus-0017-00000081035-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b6a/12013853/e44898db49e9/cureus-0017-00000081035-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b6a/12013853/3262a97285d7/cureus-0017-00000081035-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b6a/12013853/1921121cb68c/cureus-0017-00000081035-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b6a/12013853/44b77dd03883/cureus-0017-00000081035-i06.jpg

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本文引用的文献

1
Gouty Arthropathy: Review of Clinical Manifestations and Treatment, with Emphasis on Imaging.痛风性关节炎:临床表现与治疗综述,重点为影像学表现
J Clin Med. 2021 Dec 29;11(1):166. doi: 10.3390/jcm11010166.
2
Benign vs Malignant Tumors.良性肿瘤与恶性肿瘤
JAMA Oncol. 2020 Sep 1;6(9):1488. doi: 10.1001/jamaoncol.2020.2592.
3
Associations of serum uric acid level and gout with cardiac structure, function and sex differences from large scale asymptomatic Asians.大规模无症状亚洲人群血清尿酸水平和痛风与心脏结构、功能及性别差异的相关性研究。
PLoS One. 2020 Jul 20;15(7):e0236173. doi: 10.1371/journal.pone.0236173. eCollection 2020.
4
Recent developments in advanced imaging in gout.痛风的先进成像技术的最新进展。
Ther Adv Musculoskelet Dis. 2019 Apr 16;11:1759720X19844429. doi: 10.1177/1759720X19844429. eCollection 2019.
5
An unusual location of gouty panniculitis: A case report.痛风性脂膜炎的罕见部位:一例报告
Medicine (Baltimore). 2017 Apr;96(16):e6733. doi: 10.1097/MD.0000000000006733.
6
Clinical analysis of auricular benign masses.耳部良性肿物的临床分析
Korean J Audiol. 2012 Apr;16(1):10-3. doi: 10.7874/kja.2012.16.1.10. Epub 2012 Apr 30.
7
Mechanisms of joint damage in gout: evidence from cellular and imaging studies.痛风性关节炎关节损伤的机制:细胞与影像学研究证据。
Nat Rev Rheumatol. 2012 Jan 10;8(3):173-81. doi: 10.1038/nrrheum.2011.207.
8
Fine needle aspirations in oncology.肿瘤学中的细针穿刺抽吸术
Arkh Patol. 2011 Jul-Aug;73(4):21-6.
9
Ultrasound features of tophi in chronic tophaceous gout.慢性痛风石性痛风中痛风石的超声特征。
Skeletal Radiol. 2011 Mar;40(3):309-15. doi: 10.1007/s00256-010-1008-z. Epub 2010 Jul 31.
10
Cellular characterization of the gouty tophus: a quantitative analysis.痛风石的细胞特征:定量分析
Arthritis Rheum. 2010 May;62(5):1549-56. doi: 10.1002/art.27356.