Weaver Jennifer S, Vina Ernest R, Munk Peter L, Klauser Andrea S, Elifritz Jamie M, Taljanovic Mihra S
Department of Radiology, University of New Mexico, Albuquerque, NM 87131, USA.
Department of Medicine, University of Arizona Arthritis Center, Tucson, AZ 85724, USA.
J Clin Med. 2021 Dec 29;11(1):166. doi: 10.3390/jcm11010166.
Gout, a crystalline arthropathy caused by the deposition of monosodium urate crystals in the articular and periarticular soft tissues, is a frequent cause of painful arthropathy. Imaging has an important role in the initial evaluation as well as the treatment and follow up of gouty arthropathy. The imaging findings of gouty arthropathy on radiography, ultrasonography, computed tomography, dual energy computed tomography, and magnetic resonance imaging are described to include findings of the early, acute and chronic phases of gout. These findings include early monosodium urate deposits, osseous erosions, and tophi, which may involve periarticular tissues, tendons, and bursae. Treatment of gout includes non-steroidal anti-inflammatories, colchicine, glucocorticoids, interleukin-1 inhibitors, xanthine oxidase inhibitors, uricosuric drugs, and recombinant uricase. Imaging is critical in monitoring response to therapy; clinical management can be modulated based on imaging findings. This review article describes the current standard of care in imaging and treatment of gouty arthropathy.
痛风是一种由尿酸钠晶体沉积于关节及关节周围软组织所致的结晶性关节病，是引起关节疼痛的常见原因。影像学在痛风性关节病的初始评估、治疗及随访中发挥着重要作用。本文描述了痛风性关节病在X线摄影、超声、计算机断层扫描、双能计算机断层扫描及磁共振成像上的影像学表现，包括痛风早期、急性期及慢性期的表现。这些表现包括早期尿酸钠沉积、骨质侵蚀及痛风石，后者可累及关节周围组织、肌腱及滑囊。痛风的治疗包括非甾体抗炎药、秋水仙碱、糖皮质激素、白细胞介素-1抑制剂、黄嘌呤氧化酶抑制剂、促尿酸排泄药及重组尿酸酶。影像学在监测治疗反应方面至关重要；可根据影像学表现调整临床管理。本文综述了痛风性关节病影像学及治疗的当前护理标准。
