Melake Addisu, Alamnie Getachew, Mekonnen Melaku
Department of Biomedical Science, College of Health Science Debre Tabor University Debre Tabor Ethiopia.
Department of Biology, College of Natural and Computational Science Mekdela Amba University Tulu Awlya Ethiopia.
Food Sci Nutr. 2025 Apr 21;13(4):e70197. doi: 10.1002/fsn3.70197. eCollection 2025 Apr.
Many studies have shown that vitamin D deficiency and vitamin D receptor TaqI gene polymorphisms are associated with susceptibility to diabetic retinopathy in various populations. The objective of this study was to determine the impact of vitamin D deficiency and vitamin D receptor gene polymorphism on the risk of diabetic retinopathy complications in T2DM at the Debre Tabor Comprehensive Specialized Hospital, Northwest Ethiopia. 153 diabetic retinopathy patients and 153 healthy controls participated in an age- and sex-matched hospital-based case control study. To determine the related risk factors, demographic and clinical data were assessed. DNA was extracted from blood samples and subjected to polymerase chain reaction and agarose gel electrophoresis analysis to determine the genotypes. Vitamin D deficiency was detected in our investigation, and it was much more prevalent in patients than in controls (OR = 6.34, 95% CI = 3.85-10.42; 0.001). Moreover, both the tt genotype (OR: 2.18; 95% CI: 1.20-3.97; = 0.010) and t allele (OR: 1.65; 95% CI: 1.19-2.30; = 0.002) were substantially more prevalent in patients than in controls, indicating that it may be a major risk factor for the development of diabetic retinopathy. The findings point to a potential link between vitamin D deficiency and diabetic retinopathy complications. Moreover, gene polymorphisms have been linked to an increased risk of developing the disease in the Ethiopian population under study.
许多研究表明，维生素D缺乏和维生素D受体TaqI基因多态性与不同人群患糖尿病视网膜病变的易感性相关。本研究的目的是在埃塞俄比亚西北部德布雷塔博尔综合专科医院确定维生素D缺乏和维生素D受体基因多态性对2型糖尿病患者糖尿病视网膜病变并发症风险的影响。153例糖尿病视网膜病变患者和153名健康对照者参与了一项基于医院的年龄和性别匹配的病例对照研究。为了确定相关危险因素，评估了人口统计学和临床数据。从血样中提取DNA，并进行聚合酶链反应和琼脂糖凝胶电泳分析以确定基因型。在我们的调查中检测到维生素D缺乏，其在患者中的患病率远高于对照组（OR = 6.34，95% CI = 3.85 - 10.42；P < 0.001）。此外，tt基因型（OR：2.18；95% CI：1.20 - 3.97；P = 0.010）和t等位基因（OR：1.65；95% CI：1.19 - 2.30；P = 0.002）在患者中的患病率也显著高于对照组，表明它可能是糖尿病视网膜病变发生的主要危险因素。研究结果表明维生素D缺乏与糖尿病视网膜病变并发症之间可能存在联系。此外，在所研究的埃塞俄比亚人群中，基因多态性与患该疾病的风险增加有关。
