Afarid Mehrdad, Ghattavi Naghme, Johari Mohammadkarim
Poostchi Ophthalmology Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
J Ophthalmic Vis Res. 2020 Apr 6;15(2):172-177. doi: 10.18502/jovr.v15i2.6734. eCollection 2020 Apr-Jun.
To evaluate the levels of vitamin D in the serum of diabetic patients with and without diabetic retinopathy (DR).
Thirty patients with DR and thirty diabetic patients without retinopathy were included in this cross-sectional study. Based on ophthalmic examination, patients with DR were categorized into having non-proliferative retinopathy (NPDR) and proliferative retinopathy (PDR). Patients were tested for fasting blood sugar (FBS), hemoglobin A1C (HbA1C), 25-hydroxy vitamin D (25 (OH) D), and creatinine levels in the serum, and for urine protein. Vitamin D deficiency was defined as a serum 25 (OH) D level 20 ng/mL.
We found that all diabetic patients had mild vitamin D deficiency (serum 25 (OH) D level = 10-20 ng/mL). The mean serum 25 (OH) D concentration in patients with DR was lower than in those without DR (12.10 14.62 ng/mL vs 15.61 9.40 ng/mL, respectively, = 0.012). Trace or more proteinuria was frequently present in patients with DR than in those without DR (56% in DR vs 30% in non-DR; = 0.037). There were no significant differences in the FBS, HbA1C, and serum creatinine levels between patients with or without retinopathy.
The present study demonstrated that patients with DR had lower levels of serum vitamin D compared with those without retinopathy.
评估患有和未患有糖尿病视网膜病变（DR）的糖尿病患者血清中维生素D的水平。
本横断面研究纳入了30例DR患者和30例无视网膜病变的糖尿病患者。根据眼科检查，将DR患者分为非增殖性视网膜病变（NPDR）和增殖性视网膜病变（PDR）。检测患者的空腹血糖（FBS）、糖化血红蛋白（HbA1C）、血清25-羟维生素D（25(OH)D）和肌酐水平以及尿蛋白。维生素D缺乏定义为血清25(OH)D水平<20 ng/mL。
我们发现所有糖尿病患者均存在轻度维生素D缺乏（血清25(OH)D水平 = 10 - 20 ng/mL）。DR患者的血清25(OH)D平均浓度低于无DR患者（分别为12.10±14.62 ng/mL和15.61±9.40 ng/mL，P = 0.012）。DR患者中微量或更多蛋白尿的出现频率高于无DR患者（DR患者中为56%，非DR患者中为30%；P = 0.037）。有视网膜病变和无视网膜病变的患者在FBS、HbA1C和血清肌酐水平上无显著差异。
本研究表明，与无视网膜病变的患者相比，DR患者的血清维生素D水平较低。
