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从基因决定论到后基因组决定论:环境的作用再审视:《后基因组决定论:基因世纪后的环境叙事》文集引言

From genetic to postgenomic determinisms: The role of the environment reconsidered : Introduction to the collection 'Postgenomic determinisms: Environmental narratives after the century of the gene'.

作者信息

Chellappoo Azita, Baedke Jan, Meloni Maurizio

机构信息

Philosophy Department, The Open University, Milton Keynes, UK.

Department of Philosophy I, Ruhr University Bochum, Bochum, Germany.

出版信息

Hist Philos Life Sci. 2025 Apr 23;47(2):23. doi: 10.1007/s40656-025-00672-8.

DOI:10.1007/s40656-025-00672-8
PMID:40266445
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12018619/
Abstract

In the past twenty years, conceptual and technological shifts in the life sciences have unseated the causal primacy of the gene. The picture emerging from 'postgenomic' science is one that emphasises multifactorial dependencies between the environment, development, and the genome, and blurs boundaries between biological individuals, and between the body and the environment. Despite the rejection of genetic determinism within postgenomics, forms of determinism nevertheless persist. The environment is often conceptualised in postgenomic research in a narrow and constrained way, affording an outsized causal role to certain environmental factors while neglecting the influence of others. This carries ethical and social implications, including for understandings of race and motherhood. This topical collection interrogates the environmental determinisms developing within postgenomic science, through investigation of their conceptual foundations, histories, and social contexts across a range of postgenomic fields.

摘要

在过去二十年里,生命科学领域的概念和技术变革动摇了基因在因果关系中的首要地位。“后基因组”科学呈现出的图景强调环境、发育和基因组之间的多因素依赖性,模糊了生物个体之间以及身体与环境之间的界限。尽管后基因组学摒弃了基因决定论,但决定论的形式依然存在。在后基因组研究中,环境常常以一种狭隘且受限的方式被概念化,赋予某些环境因素过大的因果作用,却忽视了其他因素的影响。这带来了伦理和社会层面的影响,包括对种族和母性的理解。本专题文集通过研究后基因组科学中环境决定论在一系列后基因组领域的概念基础、历史和社会背景,对其进行审视。