Deimann W, Teckhaus L
Blood. 1985 Sep;66(3):514-21.
Computer-aided three-dimensional reconstruction of serial ultrathin sections revealed that freshly prepared monocytes from human blood contained endogenous peroxidase (PO) not only in cytoplasmic granules, but also in long contorted tubules and in complex elements, which consisted of both tubular and granular components. The various PO-positive elements formed an intricate system, which was separate from all other cytoplasmic structures, including the endoplasmic reticulum and the Golgi apparatus. Because the PO-positive elements in monocytes are known to be primary lysosomes, which are involved in host defense mechanisms, we suggest that the antimicrobial functions of human blood monocytes are exerted by functionally and morphologically diverse subcompartments of a complex system rather than by separate uniform granules.
计算机辅助的连续超薄切片三维重建显示，新鲜制备的人血单核细胞中的内源性过氧化物酶（PO）不仅存在于细胞质颗粒中，还存在于长而扭曲的小管以及由管状和颗粒状成分组成的复杂结构中。各种PO阳性结构形成了一个复杂的系统，该系统与包括内质网和高尔基体在内的所有其他细胞质结构分开。由于已知单核细胞中的PO阳性结构是参与宿主防御机制的初级溶酶体，我们认为人血单核细胞的抗菌功能是由一个复杂系统中功能和形态多样的亚区室发挥的，而不是由单独的均匀颗粒发挥的。
