Battanta Nadja, Lange Krystyna, Kesting Sabine V, Marx-Berger Daniela, Heesen Philip, Ober Hannah, Onerup Aron, Pluijm Saskia M F, Scheler Eva, Verwaaijen Emma J, Scheinemann Katrin, Otth Maria
Division of Oncology/Hematology, Children's Hospital of Eastern Switzerland, 9006 St. Gallen, Switzerland.
Department of Pediatrics, German Center for Child and Adolescent Health (DZKJ), Partner Site Munich, TUM School of Medicine and Health, Technical University of Munich, 80804 Munich, Germany.
Curr Oncol. 2025 Apr 17;32(4):234. doi: 10.3390/curroncol32040234.
A cancer diagnosis and its treatment often disrupt a child's and adolescent's normal level of physical activity, which plays a vital role in their development and health. They are therefore often less physically active during treatment than before the diagnosis or compared to healthy peers. Today, there is no comprehensive overview of the safety, feasibility, clinical effectiveness, and potentially long-lasting impact of physical activity (PA) interventions in this population. We conducted a systematic review in PubMed according to PRISMA guidelines to evaluate studies on PA interventions during cancer treatment in children and adolescents up to 25 years of age. We used the Joanna Briggs Institute's critical appraisal tools to assess the risk of bias. Due to the heterogeneity in interventions and outcomes, we used descriptive approaches only to present the results. : Half of the 21 included studies were randomized controlled trials (10/21). PA interventions were found to be safe and feasible when tailored to the patient's age, treatment phase, and clinical condition. Most studies reported improvements in physical fitness, strength, and quality of life, with some reductions in fatigue. Variability in interventions and outcomes, along with small sample sizes and heterogeneous patient populations, made it difficult to draw clear conclusions. : PA appears to be a feasible and, in terms of injuries, safe adjunct to cancer treatment in children and adolescents. Despite promising trends, further large-scale, multicenter trials with standardized protocols are needed to better establish the long-term benefits and optimal interventions.
癌症诊断及其治疗常常会打乱儿童和青少年的正常身体活动水平，而身体活动对他们的发育和健康起着至关重要的作用。因此，他们在治疗期间的身体活动往往比诊断前或与健康同龄人相比更少。如今，对于该人群中体育活动（PA）干预措施的安全性、可行性、临床有效性以及潜在的长期影响，尚无全面概述。我们根据PRISMA指南在PubMed上进行了一项系统综述，以评估针对25岁及以下儿童和青少年癌症治疗期间PA干预措施的研究。我们使用乔安娜·布里格斯研究所的批判性评估工具来评估偏倚风险。由于干预措施和结果存在异质性，我们仅采用描述性方法来呈现结果。纳入的21项研究中有一半是随机对照试验（10/21）。当根据患者的年龄、治疗阶段和临床状况进行调整时，PA干预措施被发现是安全可行的。大多数研究报告了身体素质、力量和生活质量的改善，同时疲劳有所减轻。干预措施和结果的变异性，以及样本量小和患者群体异质性，使得难以得出明确结论。PA似乎是儿童和青少年癌症治疗中一种可行且就损伤而言安全的辅助手段。尽管有令人鼓舞的趋势，但仍需要进一步开展大规模、多中心的标准化方案试验，以更好地确定长期益处和最佳干预措施。
