Burr M L, King S, Davies H E, Pathy M S
Age Ageing. 1977 Feb;6(1):38-45. doi: 10.1093/ageing/6.1.38.
The effects of discontinuing long-term diuretic therapy were investigated by means of a double-blind randomized controlled trial. A total of 141 elderly patients in the long-stay wards of six hospitals were found to be taking maintenance diuretics, and for 33 of these the drugs were judged to be mandatory. Of the remaining patients, 52 continued to receive diuretics while 54 were given matching placebo tablets. Eight in the latter group required diuretic therapy to be resumed during the following 12 weeks. The main change observed in patients who completed the trial was a slight increase of ankle oedema in the placebo group. Plasma potassium levels below 3.5 mEq/1 were found in some patients taking diuretics but not when the drugs had been withdrawn for 12 weeks. Blood pressure rose slightly in the placebo group and plasma urea rose slightly in the diuretic group. It was concluded that old people receiving long-term diuretic therapy without obvious current indication should have the drugs withdrawn under careful supervision so that those needing them could be identified.
通过双盲随机对照试验研究了停用长期利尿治疗的效果。在六家医院的长期病房中，共发现141名老年患者正在服用维持性利尿剂，其中33名患者的药物被判定为必需。在其余患者中，52名继续接受利尿剂治疗，而54名服用匹配的安慰剂片。后一组中有8名患者在接下来的12周内需要恢复利尿治疗。完成试验的患者中观察到的主要变化是安慰剂组的脚踝水肿略有增加。一些服用利尿剂的患者血浆钾水平低于3.5 mEq/1，但停药12周后未出现这种情况。安慰剂组血压略有上升，利尿剂组血浆尿素略有上升。得出的结论是，在没有明显当前指征的情况下接受长期利尿治疗的老年人应在仔细监督下停药，以便识别出需要药物治疗的患者。
