A Bibliometric Analysis and Systematic Review of Research Advances in In Situ Gel Drug Delivery Systems from 2003 to 2023.

: We aimed analyze research trends in in situ gel drug delivery systems. : Studies from 2003 to 2023 were systematically obtained from the Web of Science database and analyzed using VOSviewer software to evaluate publication trends, citation patterns, and collaborative networks. : A total of 990 articles were reviewed. There has been a significant increase in publications since 2019, with the highest number of publications occurring in 2023. China was the leading country in terms of publication output. Cairo University and King Abdulaziz University were identified as the top contributing institutions. Key researchers included Zhao, Xia, Hosny, and Kim. The research primarily focused on developing new formulations, optimizing materials (e.g., biocompatible and biodegradable materials), and exploring clinical applications such as nasal-brain delivery for Alzheimer's treatment. : In situ gel systems have gained widespread use in clinical practice due to their ability to provide prolonged drug release and enhance patient compliance. This area remains crucial for future research, particularly in formulation design and administration methods.