Zhou Huanyu, Yuan Mingqing, Zhang Tao
Guangxi Key Laboratory of Special Biomedicine, Medical School of Guangxi University, Nanning 530004, China.
Pharmaceutics. 2025 Apr 1;17(4):451. doi: 10.3390/pharmaceutics17040451.
: We aimed analyze research trends in in situ gel drug delivery systems. : Studies from 2003 to 2023 were systematically obtained from the Web of Science database and analyzed using VOSviewer software to evaluate publication trends, citation patterns, and collaborative networks. : A total of 990 articles were reviewed. There has been a significant increase in publications since 2019, with the highest number of publications occurring in 2023. China was the leading country in terms of publication output. Cairo University and King Abdulaziz University were identified as the top contributing institutions. Key researchers included Zhao, Xia, Hosny, and Kim. The research primarily focused on developing new formulations, optimizing materials (e.g., biocompatible and biodegradable materials), and exploring clinical applications such as nasal-brain delivery for Alzheimer's treatment. : In situ gel systems have gained widespread use in clinical practice due to their ability to provide prolonged drug release and enhance patient compliance. This area remains crucial for future research, particularly in formulation design and administration methods.
我们旨在分析原位凝胶给药系统的研究趋势。从2003年到2023年的研究通过Web of Science数据库系统获取，并使用VOSviewer软件进行分析，以评估出版趋势、引用模式和合作网络。共审查了990篇文章。自2019年以来，出版物数量显著增加，2023年的出版物数量最多。中国是出版物产量领先的国家。开罗大学和阿卜杜勒阿齐兹国王大学被确定为贡献最大的机构。主要研究人员包括赵、夏、霍斯尼和金。该研究主要集中在开发新剂型、优化材料（如生物相容性和可生物降解材料）以及探索临床应用，如用于阿尔茨海默病治疗的鼻脑给药。原位凝胶系统因其能够提供长效药物释放并提高患者依从性，已在临床实践中得到广泛应用。该领域对于未来研究仍然至关重要，特别是在剂型设计和给药方法方面。
