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癌症:一种现代疾病?

Cancer: A Disease of Modern Times?

作者信息

Nwosu Natasha

机构信息

Oncology, University College London Hospitals NHS Foundation Trust, London, GBR.

出版信息

Cureus. 2024 Nov 28;16(11):e74666. doi: 10.7759/cureus.74666. eCollection 2024 Nov.

Abstract

Cancer is a leading cause of mortality worldwide. Despite its prevalence, its origins remain a topic of debate, sparking discussion within the medical and historical professions. It had been feared for centuries, initially perceived as an incurable condition fraught with social stigma. This review details the historical records of cancer, tracing its earliest documented cases in ancient Egyptian and Greek civilizations, and follows the evolution of oncology treatment. Advances in medical technology and screening methods may have led to improved detection of cancer, with conditions that may have gone unnoticed in the past now diagnosed more frequently. Hippocrates and Galen later advanced the understanding of cancer by shifting from supernatural theories to a more scientific approach. The role of modifiable risk factors is highlighted, as well as the controversy surrounding the concept that cancer is a product of modern times. Environmental influences such as air pollution and tobacco smoke have been identified as carcinogenic, with public health campaigns subsequently developed. Whilst these preventative efforts aim to reduce such risks, evidence suggests that the causes of cancer are likely multi-faceted and, therefore, focusing solely on industrial factors may simplify a complex issue. The discussion remains open as to whether cancer is truly the product of modern industrialisation, or whether its low incidence in the past was due to less effective documentation and understanding. The apparent low prevalence of cancer in ancient times raises questions about the role of carcinogenic environmental factors in modern societies, with a need for continued research to explore its true origins and, therefore, develop effective strategies for prevention and treatment.

摘要

癌症是全球主要的死亡原因之一。尽管其普遍存在,但其起源仍是一个有争议的话题,引发了医学和历史学界的讨论。几个世纪以来,癌症一直令人恐惧,最初被视为一种无法治愈且充满社会耻辱感的疾病。这篇综述详细介绍了癌症的历史记录,追溯了其在古埃及和希腊文明中最早有记录的病例,并追踪了肿瘤治疗的演变。医疗技术和筛查方法的进步可能导致癌症检测得到改善,过去可能未被注意到的病症现在被诊断得更加频繁。希波克拉底和盖伦后来通过从超自然理论转向更科学的方法,推进了对癌症的认识。文中强调了可改变的风险因素的作用,以及围绕癌症是现代产物这一概念的争议。空气污染和烟草烟雾等环境影响已被确定为致癌因素,随后开展了公共卫生运动。虽然这些预防措施旨在降低此类风险,但有证据表明,癌症的病因可能是多方面的,因此,仅关注工业因素可能会简化一个复杂的问题。关于癌症是否真的是现代工业化的产物,或者过去其发病率低是否是由于记录和认识不够有效,讨论仍在继续。古代癌症明显较低的发病率引发了关于致癌环境因素在现代社会中作用的问题,需要持续研究以探索其真正起源,从而制定有效的预防和治疗策略。

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