Öztorun Z Y, Biçer G Y, Zor K R, Kardaş F
Department of Pediatrics, Niğde Ömer Halisdemir University School of Medicine, Niğde, Turkey.
Department of Ophtalmology, Niğde Ömer Halisdemir University School of Medicine, Niğde, Turkey.
Niger J Clin Pract. 2025 Apr 1;28(4):539-544. doi: 10.4103/njcp.njcp_641_24. Epub 2025 Apr 26.
Automatic pupillometry device enables important information about pupillary function. Neurological manifestations such as autonomic dysfunction and ophthalmological disorders are observed in vitamin B12 deficiency (VB12D).
To assess the static pupillary functions using a pupillometry device in pediatric patients with VB12D.
The study included 40 children with VB12D and 40 healthy children in the control group. The measurements were made with an automated pupillometry under static conditions. The static measurements were performed at scotopic, mesopic, and photopic light intensities. The differences between the patient and control groups were analyzed with static measurements.
Pupillary diameters of the patient and control groups under scotopic, mesopic, and photopic conditions were observed and there was a statistically significant difference under the mesopic and photopic conditions. Under mesopic conditions: The mean pupil diameter was found to be 5.92 ± 0.69 mm in the VB12D group and 5.18 ± 0.91 mm in the control group (P = 0.003). Under photopic conditions, the mean pupil diameter was found to be 5.13 ± 0.77 mm in the VB12D group and 4.53 ± 0.96 mm in the control group (P = 0.001). Under scotopic conditions, the mean pupil diameter was 6.46 ± 0.68 mm in the VB12D group and 6.37 ± 0.93 mm in the control group. There was no statistically significant difference between the patient and control groups in the measurements under scotopic conditions (P = 0.63).
Pediatric patients with VB12D have significantly larger pupil diameters in photopic and mesopic conditions than healthy children. The results suggest that there is an autonomic system dysfunction in children with VB12D, especially when the parasympathetic system is negatively affected. Pupillary contraction is reduced in children with VB12D. Decreased pupillary myosis function is observed. Pupillary size is larger in vitamin B12-deficient children under photopic and mesopic conditions.
自动瞳孔测量仪可获取有关瞳孔功能的重要信息。在维生素B12缺乏症（VB12D）中可观察到自主神经功能障碍和眼科疾病等神经学表现。
使用瞳孔测量仪评估VB12D患儿的静态瞳孔功能。
该研究纳入了40例VB12D患儿和40例健康儿童作为对照组。在静态条件下使用自动瞳孔测量仪进行测量。静态测量在暗视、中间视觉和明视光强度下进行。通过静态测量分析患者组和对照组之间的差异。
观察了患者组和对照组在暗视、中间视觉和明视条件下的瞳孔直径，在中间视觉和明视条件下存在统计学显著差异。在中间视觉条件下：VB12D组的平均瞳孔直径为5.92±0.69mm，对照组为5.18±0.91mm（P = 0.003）。在明视条件下，VB12D组的平均瞳孔直径为5.13±0.77mm，对照组为4.53±0.96mm（P = 0.001）。在暗视条件下，VB12D组的平均瞳孔直径为6.46±0.68mm，对照组为6.37±0.93mm。在暗视条件下的测量中，患者组和对照组之间无统计学显著差异（P = 0.63）。
VB12D患儿在明视和中间视觉条件下的瞳孔直径明显大于健康儿童。结果表明，VB12D患儿存在自主神经系统功能障碍，尤其是副交感神经系统受到负面影响时。VB12D患儿的瞳孔收缩减少。观察到瞳孔缩小功能下降。在明视和中间视觉条件下，维生素B12缺乏儿童的瞳孔尺寸更大。
