Geldwerth D, Bishop C, Guellaën G, Koenig M, Vergnaud G, Mandel J L, Weissenbach J
EMBO J. 1985 Jul;4(7):1739-43. doi: 10.1002/j.1460-2075.1985.tb03844.x.
It has been proposed that sequence homology should exist between the short arms of the human sex chromosomes, in the regions pairing at meiosis. Out of 40 clones picked at random from a collection of non-repetitive DNA sequences derived from the human Y chromosome, we have found nine sequences which show very high homology with sequences located on the X chromosome. All nine probes originate from the euchromatic part of the Y chromosome. All the homologous sequences are located within the Xq12-Xq22-24 region. None of them map to the short arm of the X chromosome. We conclude that an important part of the euchromatic region of the Y chromosome is homologous to the middle of the X chromosome long arm, possibly as a result of recent translation event(s).
有人提出，在减数分裂时配对的区域，人类性染色体的短臂之间应该存在序列同源性。从一组源自人类Y染色体的非重复DNA序列中随机挑选出40个克隆，我们发现其中9个序列与位于X染色体上的序列具有非常高的同源性。所有9个探针均来自Y染色体的常染色质部分。所有同源序列都位于Xq12 - Xq22 - 24区域内。它们都不在X染色体的短臂上定位。我们得出结论，Y染色体常染色质区域的一个重要部分与X染色体长臂的中部同源，这可能是近期发生的一次或多次易位事件的结果。
