Uemura E, Ireland W P, Levin E D, Bowman R E
Exp Neurol. 1985 Sep;89(3):503-19. doi: 10.1016/0014-4886(85)90002-0.
Dendritic growth was studied in rats exposed to halothane in utero for the entire gestation period and 60 days after birth. The exposure conditions were control, intermittent halothane (25 +/- 5 ppm or 100 +/- 5 ppm, 8 h/day, 5 days/week), or continuous halothane (25 +/- 5 ppm, 24 h/day, 7 days/week). Dendritic growth in terms of branch numbers and length was most advanced in the control groups, followed by those groups exposed to 25 +/- 5 ppm halothane intermittently, 25 +/- 5 ppm halothane continuously, and 100 +/- 5 ppm halothane intermittently. The latter two exposure conditions exerted identical effects on dendritic growth. The order of this dendritic growth level established at 5 postnatal days remained the same throughout the first 95 postnatal days in both the entorhinal cortex and subiculum. The effect of halothane on dendritic growth appeared to be enduring, and the delay in the initial dendritic growth caused by halothane was not compensated for by an increased rate of dendritic growth.
研究了在整个妊娠期及出生后60天内子宫内暴露于氟烷的大鼠的树突生长情况。暴露条件分为对照组、间歇性氟烷暴露（25±5 ppm或100±5 ppm，每天8小时，每周5天）或持续性氟烷暴露（25±5 ppm，每天24小时，每周7天）。就分支数量和长度而言，树突生长在对照组中最为显著，其次是间歇性暴露于25±5 ppm氟烷的组、持续性暴露于25±5 ppm氟烷的组以及间歇性暴露于100±5 ppm氟烷的组。后两种暴露条件对树突生长产生相同的影响。在出生后第5天确定的这种树突生长水平顺序在出生后的前95天内在内嗅皮质和海马下托中均保持不变。氟烷对树突生长的影响似乎是持久的，并且由氟烷导致的初始树突生长延迟并未因树突生长速率的增加而得到补偿。
