Aguéro-Pizzolo Stéphanie, Bettler Emmanuel, Gouet Patrice
Laboratoire de biologie tissulaire et ingénierie thérapeutique, CNRS UMR 5305, Université Lyon-1, Lyon, France.
Laboratoire de microbiologie moléculaire et de biochimie structurale, CNRS UMR 5086, Université Lyon-1, Lyon, France.
Med Sci (Paris). 2025 Apr;41(4):367-373. doi: 10.1051/medsci/2025060. Epub 2025 Apr 28.
The 2024 Nobel Prize in chemistry has been awarded to Demis Hassabis and John M. Jumper (Google DeepMind) for the development of artificial intelligence-guided protein structure prediction and to David Baker (University of Washington, Seattle, USA) for the development of computational protein design. This event marks a revolution in the field of structural biology that has led, among other things, to the generation of a library of nearly 200 million predicted protein structures designed to speed up research. This revolution in AI has also led to the design of several artificial proteins of medical interest presented in this review.
2024年诺贝尔化学奖授予了迪米斯·哈萨比斯和约翰·M·朱珀（谷歌深度思维公司），以表彰他们在人工智能引导的蛋白质结构预测方面的发展，以及授予大卫·贝克（美国西雅图华盛顿大学），以表彰他在计算蛋白质设计方面的发展。这一事件标志着结构生物学领域的一场革命，除其他成果外，这场革命还催生了一个包含近2亿个预测蛋白质结构的文库，旨在加速研究。人工智能领域的这场革命还促成了本综述中介绍的几种具有医学意义的人工蛋白质的设计。
