冷冻电镜缘何如此热门。
How Cryo-EM Became so Hot.
作者信息
Cheng Yifan, Glaeser Robert M, Nogales Eva
机构信息
Department of Biochemistry and Biophysics, and Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA, USA.
Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
出版信息
Cell. 2017 Nov 30;171(6):1229-1231. doi: 10.1016/j.cell.2017.11.016.
Abstract
The Royal Swedish Academy of Sciences awarded the 2017 Nobel Prize for Chemistry to Jacques Dubochet, Joachim Frank, and Richard Henderson for "developing cryoelectron microscopy for the high-resolution structure determination of biomolecules in solution." Achieving this goal, which required innovation, persistence, and uncommon physical insight, has broadened horizons for structural studies in molecular and cell biology.
摘要
瑞典皇家科学院将2017年诺贝尔化学奖授予雅克·迪波什、约阿希姆·弗兰克和理查德·亨德森，以表彰他们“开发了冷冻电子显微镜用于确定溶液中生物分子的高分辨率结构”。实现这一目标需要创新、毅力和非凡的物理洞察力，它拓宽了分子和细胞生物学结构研究的视野。
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