Xu Zhenyang, Mousavi Tayebeh, Ainslie Mark
Department of Engineering, King's College London, London, UK.
Drug Deliv. 2025 Dec;32(1):2490836. doi: 10.1080/10717544.2025.2490836. Epub 2025 Apr 29.
Primary bronchus cancer is one kind of lung cancer with a very high mortality rate. Magnetic drug targeting (MDT) technology could concentrate drugs in a specific area, which could have useful application in lung cancer therapy. Due to a bulk superconducting magnet's ability to generate a superior magnetic field strength and gradient in comparison to conventional permanent magnets, there is great potential for achieving MDT external to the body. However, current research in this area is still in its infancy, and numerical simulations exploring the guidance ability of this technology have been limited to only two-dimensional geometries, which limits further exploration toward clinical transformation. In this work, a three-dimensional lung and bulk superconducting magnet model have been built in the finite-element software package COMSOL Multiphysics. The model is used to simulate the drug delivery process in the lung via the superconducting magnet. The influence of various parameters on the capture efficiency is investigated, including lung-magnet distance, bulk superconductor properties, particle properties, and physiological or tumor structural parameters. The results demonstrate that the bulk superconducting magnet can effectively improve the capture efficiency of magnetic drugs or drug carriers within a suitable distance outside of the body, which could potentially guide the design of a practical, external superconducting MDT system in the near future.
原发性支气管癌是一种死亡率极高的肺癌。磁靶向给药(MDT)技术可将药物集中于特定区域,在肺癌治疗中具有潜在应用价值。与传统永磁体相比,大型超导磁体能够产生更强的磁场强度和梯度,因此在体外实现磁靶向给药具有巨大潜力。然而,该领域目前的研究仍处于起步阶段,探索这项技术导向能力的数值模拟仅限于二维几何结构,这限制了向临床转化的进一步探索。在这项工作中,在有限元软件包COMSOL Multiphysics中建立了三维肺部和大型超导磁体模型。该模型用于模拟通过超导磁体在肺部的药物递送过程。研究了各种参数对捕获效率的影响,包括肺 - 磁体距离、大块超导体特性、颗粒特性以及生理或肿瘤结构参数。结果表明,大型超导磁体能够在体外合适的距离内有效提高磁性药物或药物载体的捕获效率,这可能在不久的将来指导实用的体外超导磁靶向给药系统的设计。
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