从某植物中分离得到一种新生物碱和五种已知化合物及其抗炎活性。 （注：原文中“L.”指代不明，这里按常规翻译为“某植物”）
A new alkaloid and five known compounds from L. and their anti-inflammatory activities.
作者信息
Zhang Xiaoqian, Jiu Junlong, Wei Wenjuan, Yao Junjie, He Fan, Ying Xixiang
机构信息
School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, Liaoning, P.R. China.
School of Postgraduate, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, P.R. China.
出版信息
Nat Prod Res. 2025 Apr 29:1-9. doi: 10.1080/14786419.2025.2498070.
A new alkaloid, identified (,)-2-hydroxy-8-(4-hydroxyphenyl)-4,5-diimino-4,5-dihydro-9-1,3,6-trioxonin-9-one, named oleracimine C (), together with five known compounds, 4-hydroxybenzaldehyde (), 2-piperidone (), thymidine (), 5-hydroxypicolinic acid (), 7-hydroxy-3-(4-hydroxyphenyl)-4-chromen-4-one (), were successfully derived from L. The structures of the compounds were successfully elucidated NMR, CD, and UHPLC-ESI-Q-TOF/MS methods. Furthermore, the findings indicated that compounds , , can possess the ability to suppress the release of nitric oxide, an inflammatory factor, and demonstrate substantial anti-inflammatory effects.
一种新的生物碱，鉴定为(,)-2-羟基-8-(4-羟基苯基)-4,5-二亚氨基-4,5-二氢-9H-1,3,6-三氧杂环壬-9-酮，命名为油橄榄胺C ()，与五种已知化合物，4-羟基苯甲醛 ()、2-哌啶酮 ()、胸腺嘧啶核苷 ()、5-羟基吡啶甲酸 ()、7-羟基-3-(4-羟基苯基)-4H-色烯-4-酮 ()，成功地从油橄榄中分离得到。通过核磁共振、圆二色光谱和超高效液相色谱-电喷雾电离-四极杆-飞行时间质谱法成功阐明了这些化合物的结构。此外，研究结果表明，化合物 、 、 具有抑制炎症因子一氧化氮释放的能力，并表现出显著的抗炎作用。
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