Jafari-Vayghan Hamed, Rahimlou Mehran, Almasi-Hashiani Amir, Aframehr Ehsan, Saleh-Ghadimi Sevda
Department of Nutrition, School of Health, Arak University of Medical Sciences, Arak, Iran.
Metabolic Diseases Research Center, Health and Metabolic Research Institute, Zanjan University of Medical Science, Zanjan, Iran.
BMC Nutr. 2025 Apr 29;11(1):86. doi: 10.1186/s40795-025-01060-y.
The role of vitamin D supplementation in modulating clinical outcomes and inflammatory responses in COVID- 19 patients has garnered significant interest. This umbrella review consolidates current evidence to evaluate the association between vitamin D supplementation and COVID- 19-related outcomes.
A comprehensive search was conducted across multiple databases to identify relevant systematic reviews and meta-analyses. Studies assessing the impact of vitamin D supplementation on disease severity, mortality, hospitalization, and inflammatory markers in COVID- 19 patients were included. Methodological quality was assessed using standardized tools.
The findings suggest that vitamin D supplementation may be associated with reduced mortality and improved clinical outcomes in COVID- 19 patients. Several studies reported a decrease in inflammatory markers, such as C-reactive protein and interleukin- 6, following supplementation. However, variations in study design, dosage regimens, and baseline vitamin D status limit the generalizability of results.
Vitamin D supplementation appears to have a potential role in improving clinical outcomes and modulating inflammatory responses in COVID- 19 patients. Nevertheless, due to heterogeneity among studies, further high-quality randomized controlled trials are warranted to confirm these findings.
补充维生素D对新冠病毒肺炎（COVID-19）患者临床结局及炎症反应的调节作用已引起广泛关注。本综述整合现有证据，以评估补充维生素D与COVID-19相关结局之间的关联。
对多个数据库进行全面检索，以识别相关的系统评价和荟萃分析。纳入评估补充维生素D对COVID-19患者疾病严重程度、死亡率、住院率及炎症标志物影响的研究。使用标准化工具评估方法学质量。
研究结果表明，补充维生素D可能与COVID-19患者死亡率降低及临床结局改善有关。多项研究报告称，补充维生素D后炎症标志物如C反应蛋白和白细胞介素-6有所下降。然而，研究设计、剂量方案及基线维生素D状态的差异限制了结果的普遍性。
补充维生素D似乎在改善COVID-19患者临床结局及调节炎症反应方面具有潜在作用。尽管如此，由于研究之间存在异质性，仍需进一步开展高质量的随机对照试验来证实这些发现。
