Zhang Leyi, Zhang Pengfei, Xu Ge, Song Kevin Sun, Liang Tairun, Peng Jiawei, Wu Shoutang, Yang Ningjia, Wang Lin, Liu Yanling, Zhang Xinming, Liang Pengshuai, Xu Zheng, Song Changxu
College of Animal Science & National Engineering Center for Swine Breeding Industry, South China Agricultural University, Guangzhou 510642, China.
Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Transbound Emerg Dis. 2023 Feb 27;2023:6694913. doi: 10.1155/2023/6694913. eCollection 2023.
is a fatal Gram-negative bacterium which could infect human beings. Our investigation found severe piglet diarrhea in one farm; the morbidity rate of piglets was 30.65%. Then, we isolated a nonpigmented, -hemolytic Gram-negative bacillus from the clinical samples of this farm, which was designated GDHYZ30 strain. The 16S rRNA gene sequence indicated it was most closely related to . Similar clinical symptoms were successfully reproduced in experimental piglets with this isolate, and the isolate was also subjected to whole genome-sequencing. It is worth noting that this has been isolated from several other pig farms with diarrhea of unknown causes. To our knowledge, this is the first report that discusses as a new pathogen causing diarrhea and death in piglets and transmitting through water sources, and it provides a reference for the prevention and control of human/animal infections as well as food safety.
是一种可感染人类的致命革兰氏阴性菌。我们的调查发现一个猪场出现严重的仔猪腹泻；仔猪发病率为30.65%。然后，我们从该猪场的临床样本中分离出一株无色素、β溶血的革兰氏阴性杆菌，命名为GDHYZ30菌株。16S rRNA基因序列表明它与 关系最为密切。用该分离株在实验仔猪中成功再现了相似的临床症状，并且对该分离株进行了全基因组测序。值得注意的是，这种 还从其他几个病因不明的腹泻猪场中分离出来。据我们所知，这是首次报道 将 作为一种导致仔猪腹泻和死亡并通过水源传播的新病原体进行讨论，它为预防和控制人/动物感染以及食品安全提供了参考。
