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养殖蓝狐中一种新发传染病（大肾病）的新型病原体。

A Novel Pathogen of an Emerging Infectious Disease (Large Kidney Disease) in Farmed Blue Foxes.

作者信息

Wang Yumao, Gu Chenchen, Han Qiang, Fu Shijun, Wang Jianjun, Zhuang Jinqiu, Guo Guangjun, Liu Jinfeng, Yu Xinyou, Qu Guanggang, Shen Zhiqiang

机构信息

Shandong Binzhou Animal Science and Veterinary Medicine Academy, Binzhou 256600, Shandong, China.

College of Biology, China Agricultural University, Beijing 100019, China.

出版信息

Transbound Emerg Dis. 2023 Aug 1;2023:6629054. doi: 10.1155/2023/6629054. eCollection 2023.

DOI:10.1155/2023/6629054
PMID:40303833
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12017029/
Abstract

An emerging infectious disease (EID) in foxes called "large kidney disease", characterized by enlarged kidneys, has been breaking out in fox farms in China, although its pathogenesis has not yet been elucidated. Here, we performed viral metagenomics sequencing on diseased fox tissue samples that identified a virus with 82.6% homology to the xenotropic murine leukemia virus-related virus (XMRV) PreXMRV-1 provirus strain (GenBank accession number NC_007815.2) in sick fox tissue. It was named PreXMRV-20, and its genome was verified by reverse transcription-polymerase chain reaction (PCR) and PCR product sequencing. Nonenveloped and polygonal virus-like particles consistent with the shape and size of XMRV were observed by negative staining electron microscopy. Administered subcutaneously, PreXMRV-20 infected weaned foxes, leading to growth retardation. The discovery of the PreXMRV-20 strain (the first isolation of an XMRV homolog in blue foxes) identifies a potential public health issue in blue fox breeding since XMRV has been confirmed to be a zoonotic virus.

摘要

一种名为“大肾病”的狐狸新发传染病在中国狐狸养殖场爆发，其特征为肾脏肿大，尽管其发病机制尚未阐明。在此，我们对患病狐狸组织样本进行了病毒宏基因组测序，在患病狐狸组织中鉴定出一种与嗜异性小鼠白血病病毒相关病毒（XMRV）前病毒PreXMRV-1毒株（GenBank登录号NC_007815.2）具有82.6%同源性的病毒。它被命名为PreXMRV-20，其基因组通过逆转录-聚合酶链反应（PCR）和PCR产物测序进行了验证。通过负染电子显微镜观察到与XMRV形状和大小一致的无包膜多边形病毒样颗粒。皮下接种PreXMRV-20可感染断奶狐狸，导致生长发育迟缓。PreXMRV-20毒株的发现（首次在蓝狐中分离出XMRV同源物）确定了蓝狐养殖中潜在的公共卫生问题，因为XMRV已被证实为人畜共患病病毒。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7e/12017029/156153956a07/TBED2023-6629054.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7e/12017029/962b7ae76be6/TBED2023-6629054.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7e/12017029/242fd194dcd6/TBED2023-6629054.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7e/12017029/7072440ecc35/TBED2023-6629054.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7e/12017029/9cb47bbb0892/TBED2023-6629054.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7e/12017029/02d09184cb11/TBED2023-6629054.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7e/12017029/35ff47f7a8dd/TBED2023-6629054.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7e/12017029/42b9c843305d/TBED2023-6629054.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7e/12017029/a27c5638ef32/TBED2023-6629054.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7e/12017029/156153956a07/TBED2023-6629054.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7e/12017029/962b7ae76be6/TBED2023-6629054.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7e/12017029/242fd194dcd6/TBED2023-6629054.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7e/12017029/7072440ecc35/TBED2023-6629054.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7e/12017029/9cb47bbb0892/TBED2023-6629054.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7e/12017029/02d09184cb11/TBED2023-6629054.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7e/12017029/35ff47f7a8dd/TBED2023-6629054.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7e/12017029/42b9c843305d/TBED2023-6629054.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7e/12017029/a27c5638ef32/TBED2023-6629054.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e7e/12017029/156153956a07/TBED2023-6629054.009.jpg

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