Western Michigan University, Homer Stryker MD School of Medicine, Kalamazoo, Michigan, USA.
Department of Dermatology, Wayne State University School of Medicine, Detroit, Michigan, USA.
Clin Dermatol. 2021 Jul-Aug;39(4):688-694. doi: 10.1016/j.clindermatol.2021.05.024. Epub 2021 May 19.
Plantar warts are among the most common skin conditions and are classically resistant to treatment. To perform an evidence-based evaluation of the efficacy and safety of available treatment options for plantar warts, we conducted a systematic review of PubMed and Cochrane databases to identify large interventional and observational studies involving more than 100 patients who were treated for plantar warts from inception to October 2020. We identified only nine contributions meeting our inclusion criteria (N ≥ 100), representing 1,657 adult and pediatric patients with plantar warts. Treatments included in this review were topical keratolytic agents, cryotherapy, laser therapies, and intralesional and systemic treatments. Our evidence-based review of the larger studies suggests keratolytic agents and destructive treatments, in particular salicylic acid and cryotherapy, remain the primary treatments for plantar warts. Treatment with pulsed dye laser had the lowest rate of recurrence. Newer treatments and intralesional treatments were not represented owing to lack of large studies involving these modalities.
足底疣是最常见的皮肤疾病之一，通常对治疗有抵抗力。为了对足底疣现有治疗选择的疗效和安全性进行基于证据的评估，我们对 PubMed 和 Cochrane 数据库进行了系统回顾，以确定从开始到 2020 年 10 月涉及 100 多名患者的大型干预性和观察性研究，这些患者因足底疣接受了治疗。我们仅确定了符合纳入标准的 9 项研究（N ≥ 100），涉及 1657 名成人和儿科足底疣患者。本综述中包括的治疗方法有局部角质松解剂、冷冻疗法、激光疗法以及病灶内和全身治疗。我们对较大规模研究的循证综述表明，角质松解剂和破坏性治疗，特别是水杨酸和冷冻疗法，仍然是足底疣的主要治疗方法。脉冲染料激光治疗的复发率最低。由于缺乏涉及这些方法的大型研究，因此新型治疗方法和病灶内治疗方法未被列入。
