Liu Xiaofeng, Nan Fuyao, An Peng, Deng Kangli, Li Lei, Wang Hongwu
Department of Respiratory Medicine, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Beijing University of Chinese Medicine, Beijing, China.
Front Med (Lausanne). 2025 Apr 16;12:1557549. doi: 10.3389/fmed.2025.1557549. eCollection 2025.
To explore the efficacy of thermal ablation combined with percutaneous injection of amphotericin B in the treatment of chronic pulmonary aspergillosis.
Case 1 was a 66-year-old female, whose computed tomography (CT) showed a space-occupying lesion in the upper lobe of the right lung. Case 2 was a 48-year-old female, and her CT scan revealed an eccentric cavity in the upper right lung accompanied by the formation of an aspergilloma. Case 3 was a 40-year-old male, and his CT indicated the formation of an aspergilloma within the cavity in the upper lobe of the left lung. All three patients had a history of pulmonary tuberculosis and were diagnosed with pulmonary aspergillosis in other hospitals. Due to the unsatisfactory effect of oral triazole drugs, they finally came to our hospital to receive the treatment of thermal ablation combined with percutaneous injection of amphotericin B. They recovered well after the operation without significant complications.
During the follow-up period ranging from 1 month to 2 years after discharge, the patients reported no discomfort symptoms such as hemoptysis or chest pain. CT scans showed that the lesions were stable and even absorbed compared with those before treatment. The patients recovered well.
The combination of thermal ablation and percutaneous injection of amphotericin B in the treatment of chronic pulmonary aspergillosis can significantly improve the clinical symptoms of patients and enhance their quality of life. It may become a treatment method for chronic pulmonary aspergillosis.
探讨热消融联合经皮注射两性霉素B治疗慢性肺曲霉病的疗效。
病例1为一名66岁女性，其计算机断层扫描（CT）显示右肺上叶有占位性病变。病例2为一名48岁女性，其CT扫描显示右上肺有偏心空洞并伴有曲霉菌瘤形成。病例3为一名40岁男性，其CT显示左肺上叶空洞内有曲霉菌瘤形成。所有3例患者均有肺结核病史，在其他医院被诊断为肺曲霉病。由于口服三唑类药物效果不佳，他们最终来我院接受热消融联合经皮注射两性霉素B治疗。术后恢复良好，无明显并发症。
出院后1个月至2年的随访期间，患者均未出现咯血、胸痛等不适症状。CT扫描显示，与治疗前相比，病变稳定甚至吸收。患者恢复良好。
热消融联合经皮注射两性霉素B治疗慢性肺曲霉病可显著改善患者临床症状，提高生活质量，可能成为慢性肺曲霉病的一种治疗方法。
