Rosato Miriam, Sala Marco, Coccaro Ambra, Cutini Simone, Liotti Mario
Department of Developmental and Social Psychology, University of Padova, Via Venezia 8, 35131 Padova, Italy.
Padova Neuroscience Center, University of Padova, Via Orus 2/B, 35129 Padova, Italy.
Brain Sci. 2025 Mar 27;15(4):343. doi: 10.3390/brainsci15040343.
: The aims of the study were to test the short-term and long-term efficacy of repetitive γ-tACS over the left DLPFC to improve visuospatial working memory performance in the spatial capacity delayed response task (SCDRT). : In a single blind placebo-controlled study, 35 healthy young adults were randomly assigned to three sessions of either active γ-tACS (n = 18) or passive sham γ-tACS (n = 17) The design allowed us to evaluate the influence of the stimulation protocol (active vs. sham), the stimulation session number (day 1 to 3), the session block (before stimulation, during stimulation and after stimulation) and the VSWM retention load (1, 3, 5 or 7 stimuli) on the response speed and accuracy. : Active γ-tACS selectively improved VSWM performance on day 2 and 3, and the effect was greater following stimulation rather than during stimulation. Significant effects were seen concerning response speed but not accuracy. The VSWM performance gains of the active γ-tACS were no longer present in the long-term at a follow-up session after two weeks. : The present study provides novel evidence for a selective improvement in VSWM performance with three repeated sessions of γ-tACS in young adults through the entrainment of gamma rhythms in the left DLPFC.
本研究的目的是测试经颅交流电刺激（γ-tACS）重复作用于左侧背外侧前额叶皮质（DLPFC）的短期和长期疗效，以改善空间能力延迟反应任务（SCDRT）中的视觉空间工作记忆表现。在一项单盲安慰剂对照研究中，35名健康的年轻成年人被随机分配到三组，分别接受三次主动γ-tACS（n = 18）或被动伪γ-tACS（n = 17）。该设计使我们能够评估刺激方案（主动与伪刺激）、刺激次数（第1天至第3天）、时段分组（刺激前、刺激期间和刺激后）以及视觉空间工作记忆（VSWM）保持负荷（1、3、5或7个刺激）对反应速度和准确性的影响。主动γ-tACS在第2天和第3天选择性地改善了VSWM表现，且刺激后而非刺激期间的效果更大。在反应速度方面观察到显著影响，但在准确性方面未观察到。主动γ-tACS带来的VSWM表现提升在两周后的随访中不再长期存在。本研究提供了新的证据，表明在年轻成年人中，通过夹带左侧DLPFC中的γ节律，三次重复的γ-tACS可选择性改善VSWM表现。
