Soltero Erica G, Salim Osamah, Mirabile Yiming, Musaad Salma M
USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates Street, Houston, TX 77030, USA.
Children (Basel). 2025 Apr 16;12(4):513. doi: 10.3390/children12040513.
: Time spent in sedentary pursuits is associated with adverse metabolic profiles. Adolescents spend 65-75% of their day in sedentary pursuits; however, evidence among youth is less conclusive. This study examined the effects of an acute 4 h bout of sedentary behaviors on cardiometabolic outcomes and energy expenditure in Hispanic adolescents (12-16 years old) with obesity (BMI% ≥ 95th). : This study used a randomized cross-over design to engage participants (N = 12) in two sedentary conditions, an active condition where youth were engaged in two hours of 'active' sitting activities (e.g., reading and puzzles) and two hours of passive movie-watching. Whole-room calorimetry was used to assess energy expenditure. Fasting measures of insulin, adiponectin, leptin, and TNF-alpha were collected, followed by post-prandial measures 30 min, 2 h, and 4 h after a standardized meal. Adiposity was assessed using DXA. : There was no overall impact of the 4 h sedentary bout on energy expenditure or cardiometabolic risk factors; however, energy expenditure in the active sedentary condition was higher compared to the passive sedentary condition ( = 0.0635, ß estimate = 0.1538). Sex and adiposity did not moderate the relationships among sedentary time, cardiometabolic outcomes, and energy expenditure. : Due to power limitations, these results are exploratory; however, they suggest that different types of sedentary behaviors may be more deleterious than others. More studies are needed to understand the context in which sedentary activities occur and the mechanisms by which sedentary pursuits contribute to the development of cardiometabolic disease.
久坐不动的行为所花费的时间与不良代谢状况相关。青少年一天中65 - 75%的时间处于久坐状态；然而，在年轻人中的证据尚不确凿。本研究考察了4小时急性久坐行为对肥胖的西班牙裔青少年（12 - 16岁，BMI%≥第95百分位）的心脏代谢指标和能量消耗的影响。：本研究采用随机交叉设计，让参与者（N = 12）处于两种久坐条件下，一种是活跃条件，即年轻人进行两小时的“活跃”坐姿活动（如阅读和拼图），然后两小时的被动观影。使用全室量热法评估能量消耗。收集空腹时胰岛素、脂联素、瘦素和肿瘤坏死因子-α的测量值，随后在标准餐后30分钟、2小时和4小时收集餐后测量值。使用双能X线吸收法评估肥胖程度。：4小时的久坐行为对能量消耗或心脏代谢风险因素没有总体影响；然而，与被动久坐条件相比，活跃久坐条件下的能量消耗更高（P = 0.0635，β估计值 = 0.1538）。性别和肥胖程度并未调节久坐时间、心脏代谢指标和能量消耗之间的关系。：由于样本量限制，这些结果具有探索性；然而，它们表明不同类型的久坐行为可能比其他行为更有害。需要更多研究来了解久坐活动发生的背景以及久坐行为导致心脏代谢疾病发展的机制。
