Department of Family Medicine and Public Health UC San Diego La Jolla CA.
Department of Medicine UC San Diego La Jolla CA.
J Am Heart Assoc. 2020 Feb 18;9(4):e013403. doi: 10.1161/JAHA.119.013403. Epub 2020 Feb 17.
Background Sedentary behavior is pervasive, especially in older adults, and is associated with cardiometabolic disease and mortality. Relationships between cardiometabolic biomarkers and sitting time are unexplored in older women, as are possible ethnic differences. Methods and Results Ethnic differences in sitting behavior and associations with cardiometabolic risk were explored in overweight/obese postmenopausal women (n=518; mean±SD age 63±6 years; mean body mass index 31.4±4.8 kg/m). Accelerometer data were processed using validated machine-learned algorithms to measure total daily sitting time and mean sitting bout duration (an indicator of sitting behavior pattern). Multivariable linear regression was used to compare sitting among Hispanic women (n=102) and non-Hispanic women (n=416) and tested associations with cardiometabolic risk biomarkers. Hispanic women sat, on average, 50.3 minutes less/day than non-Hispanic women (<0.001) and had shorter (3.6 minutes less, =0.02) mean sitting bout duration. Among all women, longer total sitting time was deleteriously associated with fasting insulin and triglyceride concentrations, insulin resistance, body mass index and waist circumference; longer mean sitting bout duration was deleteriously associated with fasting glucose and insulin concentrations, insulin resistance, body mass index and waist circumference. Exploratory interaction analysis showed that the association between mean sitting bout duration and fasting glucose concentration was significantly stronger among Hispanic women than non-Hispanic women (-interaction=0.03). Conclusions Ethnic differences in 2 objectively measured parameters of sitting behavior, as well as detrimental associations between parameters and cardiometabolic biomarkers were observed in overweight/obese older women. The detrimental association between mean sitting bout duration and fasting glucose may be greater in Hispanic women than in non-Hispanic women. Corroboration in larger studies is warranted.
久坐行为普遍存在，尤其是在老年人中，与心血管代谢疾病和死亡率有关。超重/肥胖绝经后妇女中，心血管代谢生物标志物与坐姿时间的关系以及可能存在的种族差异尚未得到探索。
本研究在超重/肥胖绝经后妇女（n=518；平均年龄 63±6 岁；平均 BMI 31.4±4.8 kg/m2）中探讨了坐姿行为和与心血管代谢风险的关系。使用经过验证的机器学习算法处理加速度计数据，以测量总日常坐姿时间和平均坐姿持续时间（坐姿行为模式的指标）。多变量线性回归用于比较西班牙裔女性（n=102）和非西班牙裔女性（n=416）的坐姿，并测试与心血管代谢风险生物标志物的相关性。与非西班牙裔女性相比，西班牙裔女性平均每天少坐 50.3 分钟（<0.001），平均坐姿持续时间短 3.6 分钟（=0.02）。在所有女性中，总坐姿时间较长与空腹胰岛素和甘油三酯浓度、胰岛素抵抗、BMI 和腰围呈负相关；较长的平均坐姿持续时间与空腹血糖和胰岛素浓度、胰岛素抵抗、BMI 和腰围呈负相关。探索性交互分析显示，在西班牙裔女性中，平均坐姿持续时间与空腹血糖浓度之间的相关性明显强于非西班牙裔女性（-交互=0.03）。
在超重/肥胖的老年女性中，观察到两种客观测量的坐姿行为参数存在种族差异，以及这些参数与心血管代谢生物标志物之间的有害关联。平均坐姿持续时间与空腹血糖之间的有害关联在西班牙裔女性中可能比非西班牙裔女性更大。需要更大规模的研究来证实这一点。
