Jung Jungwoo, Lee Seunghee, Lee Jungwon, Ko Young-Chang, Lee Dongseob, Seol Yang-Jo, Koo Ki-Tae, Lee Yong-Moo
Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
One-Stop Specialty Center, Seoul National University Dental Hospital, Seoul, Korea.
J Periodontal Implant Sci. 2025 Apr;55(2):139-152. doi: 10.5051/jpis.2402100105.
We examined the progression of experimental peri-implantitis in sites that underwent either alveolar ridge preservation (ARP) or spontaneous healing (SH), comparing infected teeth (IT) and non-infected teeth (NIT). This investigation is a secondary analysis of a preclinical study aimed at exploring the correlation between newly formed bone and implant stability quotient (ISQ), as well as the association between newly formed bone and the progression of experimental peri-implantitis.
The bilateral mandibular third or fourth premolars of 6 beagle dogs were randomly assigned to 4 groups: IT/SH, IT/ARP, NIT/SH, and NIT/ARP. Following implant placement, core biopsies were retrieved from each site, and the ISQ value was measured. A 3-month period was allowed for peri-implantitis induction, followed by an additional 3 months for the spontaneous progression of peri-implantitis, with radiographs taken at each time point.
During the spontaneous progression of peri-implantitis, no statistically significant differences were observed among the groups in terms of mean ISQ values and radiographic marginal bone loss. Similarly, the percentages of bone substitute, newly formed bone, and fibrovascular connective tissue in core biopsies did not differ significantly among the groups. Linear regression analysis revealed no significant linear correlation between newly formed bone and ISQ in any group (>0.05). However, a weak linear correlation between newly formed bone and marginal bone loss during the spontaneous progression of peri-implantitis was noted in the IT/SH group alone (=0.036).
Within the limitations of this study, we were unable to demonstrate that ARP could improve newly formed bone or primary implant stability. Furthermore, neither ARP nor SH significantly influenced the spontaneous progression of experimental peri-implantitis.
我们研究了在接受牙槽嵴保存（ARP）或自然愈合（SH）的部位，实验性种植体周围炎在感染牙（IT）和非感染牙（NIT）中的进展情况。本研究是一项临床前研究的二次分析，旨在探讨新形成的骨与种植体稳定性商数（ISQ）之间的相关性，以及新形成的骨与实验性种植体周围炎进展之间的关联。
将6只比格犬的双侧下颌第三或第四前磨牙随机分为4组：IT/SH、IT/ARP、NIT/SH和NIT/ARP。种植体植入后，从每个部位获取核心活检样本，并测量ISQ值。给予3个月的时间诱导种植体周围炎，随后再给予3个月的时间让种植体周围炎自然进展，每个时间点都拍摄X线片。
在种植体周围炎自然进展过程中，各组间的平均ISQ值和X线片上的边缘骨丢失量无统计学显著差异。同样，核心活检样本中骨替代物、新形成的骨和纤维血管结缔组织的百分比在各组间也无显著差异。线性回归分析显示，任何组中新形成的骨与ISQ之间均无显著线性相关性（>0.05）。然而，仅在IT/SH组中，注意到在种植体周围炎自然进展过程中新形成的骨与边缘骨丢失之间存在微弱的线性相关性（=0.036）。
在本研究的局限性内，我们无法证明牙槽嵴保存能改善新形成的骨或种植体的初始稳定性。此外，牙槽嵴保存和自然愈合均未显著影响实验性种植体周围炎的自然进展。
