Brock Nicole, Pulit-Penaloza Joanna A, Belser Jessica A, Pappas Claudia, Sun Xiangjie, Kieran Troy J, Zeng Hui, De La Cruz Juan A, Hatta Yasuko, Di Han, Davis C Todd, Tumpey Terrence M, Maines Taronna R
Emerg Infect Dis. 2025 Jun;31(6):1253-6. doi: 10.3201/eid3106.250386. Epub 2025 May 2.
Influenza A(H5N1) viruses have been detected in US dairy cow herds since 2024. We assessed the pathogenesis, transmission, and airborne release of A/Michigan/90/2024, an H5N1 isolate from a dairy farm worker in Michigan, in the ferret model. Results show this virus caused airborne transmission with moderate pathogenicity, including limited extrapulmonary spread, without lethality.
自2024年以来，在美国奶牛群中检测到甲型流感病毒（H5N1）。我们在雪貂模型中评估了从密歇根州一名奶牛场工人身上分离出的H5N1毒株A/密歇根/90/2024的发病机制、传播情况和空气传播释放。结果表明，这种病毒具有中等致病性，可通过空气传播，包括有限的肺外传播，且无致死性。
