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子宫颈癌大规模筛查中细胞采样方法的研究——棉签拭子、木质刮板及棉签拭子加阴道镜检查所获数据的比较

[Studies on a cell sampling method in mass screening for uterine cervical cancer--comparison of data obtained with a cotton tipped applicator, wooden spatula and cotton tipped applicator plus colposcopy].

作者信息

Takahashi K, Yamane Y, Yoshino K, Shibukawa T, Yamamoto K, Iwanari O, Matsunaga I, Kitao M

出版信息

Nihon Sanka Fujinka Gakkai Zasshi. 1985 Jul;37(7):1117-24.

PMID:4031569
Abstract

In mass screening tests for uterine cancer carried out Shimane Prefecture, we used three different scraping methods. This summary is a report of a comparison of the findings with each method. Results are as follows: From 1973-1982, 214, 798 Japanese women were examined in mass screening tests. Among the 42, 443 examined using a cotton tipped applicator, there were 15 (0.035%) with mild dysplasia, 8 (0.019%) with severe dysplasia, 6 (0.014%) with carcinoma in situ and 8 (0.019%) with invasive carcinoma. In 38,106 women examined using the spatula, 25 (0.066%) had a mild dysplasia, 10 (0.026%) a severe dysplasia, 18 (0.047%) a carcinoma in situ and 26 (0.068%) an invasive carcinoma. In 134,249 examined using a cotton tipped applicator plus colposcopy, 283 (0.211%) had a mild dysplasia 108 (0.080%) a severe dysplasia, 57 (0.042%) a carcinoma in situ and 78 (0.058%) an invasive carcinoma. Thus, the use of a cotton tipped applicator plus colposcopy leads to higher rates of detection of mild and severe dysplasia. In the group with a negative Papanicolaou smear and for whom the cotton tipped applicator plus colposcopy was used, there were 214 with a mild dysplasia, 65 with a severe dysplasia, 11 with a carcinoma in situ and 7 with an invasive carcinoma. The combination of cotton tipped applicator and colposcopy proved to be the most effective for mass screenings for uterine cancer, as the detection rates for severe dysplasia and carcinoma in situ were higher and there were fewer incidences of false negative results.

摘要

在岛根县开展的子宫癌大规模筛查试验中,我们采用了三种不同的刮片方法。本总结报告了对每种方法的检查结果进行比较的情况。结果如下:1973年至1982年期间,对214,798名日本女性进行了大规模筛查。在使用棉拭子检查的42,443名女性中,有15名(0.035%)为轻度发育异常,8名(0.019%)为重度发育异常,6名(0.014%)为原位癌,8名(0.019%)为浸润癌。在使用刮板检查的38,106名女性中,25名(0.066%)有轻度发育异常,10名(0.026%)有重度发育异常,18名(0.047%)有原位癌,26名(0.068%)有浸润癌。在使用棉拭子加阴道镜检查的134,249名女性中,283名(0.211%)有轻度发育异常,108名(0.080%)有重度发育异常,57名(0.042%)有原位癌,78名(0.058%)有浸润癌。因此,使用棉拭子加阴道镜检查可提高轻度和重度发育异常的检出率。在巴氏涂片检查结果为阴性且使用棉拭子加阴道镜检查的人群中,有214名轻度发育异常,65名重度发育异常,11名原位癌,7名浸润癌。事实证明,棉拭子和阴道镜检查相结合对于子宫癌的大规模筛查最为有效,因为重度发育异常和原位癌的检出率更高,假阴性结果的发生率更低。

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