Shehzad Adeeb, Qureshi Munibah, Jabeen Saima, Ahmad Rizwan, Alabdalall Amira H, Aljafary Meneerah Abdulrahman, Al-Suhaimi Ebtesam
Department of Biomedical Engineering and Sciences, School of Mechanical and Manufacturing Engineering, National University of Science and Technology, Islamabad, Pakistan.
College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
PeerJ. 2018 Dec 17;6:e6086. doi: 10.7717/peerj.6086. eCollection 2018.
Green synthesis of metallic nanoparticles has gained significant attention in the field of nanomedicine as an environment-friendly and cost-effective alternative in comparison with other physical and chemical methods. Several metals such as silver, gold, iron, titanium, zinc, magnesium and copper have been subjected to nanoformulation for a wide range of useful applications. Silver nanoparticles (AgNPs) are playing a major role in the field of nanomedicine and nanotechnology. They are widely used in diagnostics, therapeutic and pharmaceutical industries. Studies have shown potential inhibitory antimicrobial, anti-inflammatory and antiangiogenesis activities of AgNPs.
AgNPs have been synthesized using silver nitrate and methanolic root extract of that belongs to the family. Stability and dispersion of nanoparticles were improved by adding xylitol. Synthesized nanoparticles were characterized by UV-Vis spectroscopy, scanning electron microscopy, energy dispersive spectroscopy, X-ray diffractometer and Fourier transforms infrared spectroscopy. Furthermore, the antibacterial effect of the plant extract and the nanoparticles were evaluated against gram-positive () and gram-negative () bacteria.
The average size of AgNPs synthesized, was 20 nm with the spherical shape. based nanoparticles exhibited improved antibacterial activity against both gram-positive and negative strains.
与其他物理和化学方法相比，金属纳米颗粒的绿色合成作为一种环境友好且经济高效的替代方法，在纳米医学领域受到了广泛关注。银、金、铁、钛、锌、镁和铜等几种金属已被制成纳米制剂用于广泛的有用应用。银纳米颗粒（AgNPs）在纳米医学和纳米技术领域发挥着重要作用。它们广泛应用于诊断、治疗和制药行业。研究表明AgNPs具有潜在的抗菌、抗炎和抗血管生成活性。
使用硝酸银和属于 科的 的甲醇根提取物合成了AgNPs。通过添加木糖醇改善了纳米颗粒的稳定性和分散性。通过紫外可见光谱、扫描电子显微镜、能量色散光谱、X射线衍射仪和傅里叶变换红外光谱对合成的纳米颗粒进行了表征。此外，还评估了植物提取物和纳米颗粒对革兰氏阳性（ ）和革兰氏阴性（ ）细菌的抗菌效果。
合成的AgNPs平均尺寸为20 nm，呈球形。基于 的纳米颗粒对革兰氏阳性和阴性菌株均表现出增强的抗菌活性。
