来自澳石南属植物的抗肿瘤及杀鱼用1-烷基瑞香烷原酸酯

Antineoplastic and piscicidal 1-alkyldaphnane orthoesters from Pimelea species.

作者信息

Tyler M I, Howden M E

出版信息

J Nat Prod. 1985 May-Jun;48(3):440-5. doi: 10.1021/np50039a012.

PMID:4031900

Abstract

Five biologically active daphnane orthoesters have been isolated from Pimelea species (Thymelaeaceae). Four of these possessing antineoplastic activity against in vivo murine P-388 lymphocytic leukemia are gnidimacrin from P. ligustrina, simpleximacrin from P. simplex, linimacrin d and Pimelea factor P3 from P. linifolia. Linimacrin c from P. linifolia and the other four compounds showed piscicidal activity. Gnidimacrin and Pimelea factor P3 have previously been isolated from other members of the Thymelaeaceae. Simpleximacrin and linimacrins c and d are new compounds.

摘要

从瑞香科白叶莓属植物中分离出了五种具有生物活性的瑞香烷原酸酯。其中四种对体内小鼠P-388淋巴细胞白血病具有抗肿瘤活性，它们分别是来自女贞叶白叶莓的gnidimacrin、来自单叶白叶莓的simpleximacrin、来自亚麻叶白叶莓的linimacrin d和白叶莓因子P3。来自亚麻叶白叶莓的linimacrin c以及其他四种化合物具有杀鱼活性。Gnidimacrin和白叶莓因子P3此前已从瑞香科的其他植物中分离出来。Simpleximacrin以及linimacrins c和d是新化合物。