Sasaoka Shun, Gabe Yu, Uchiyama Masayuki, Stepp Anita, Imai Asuka, Hachiya Akira, Kiyomine Akira
Kao Corporation, Skin Care Products Research, Sumida-ku, Tokyo, Japan.
Kao Corporation, Biological Science Research, Kotobuki-cho, Odawara-shi, Kanagawa, Japan.
Skin Res Technol. 2025 Feb-May;31(2-5):e70161. doi: 10.1111/srt.70161.
Dry skin is a universal skin concern that is often accompanied by itching, but moisturizers have not completely solved this issue. We found that the combination of a moisturizer (lotion) and an ultra-thin film of fine fiber (FF) that we developed improved dry skin early, but the biological mechanism within the skin remained unclear.
Eight (Study 1) and seven (Study 2) subjects used a lotion with and without the FF film on their lower legs. In addition to measurement of visual skin dryness scores and conductance, proteomic analysis of stratum corneum (SC) samples at baseline and 14 days after treatment in Study 1 and immunohistochemical staining of skin biopsy samples 3 or 5 days after treatment in Study 2 were performed.
Skin dryness scores and conductance improved more when the lotion was used with the FF film than with the lotion alone. The protein expression level of suprabasin, which is related to epidermal differentiation and barrier function, increased within a few days near the granular layer, as well as in the SC after 14 days. Proteomic analysis using SC samples showed that the FF film treatment with lotion decreased annexin A2, a dry skin marker, whereas it increased retroviral-like aspartic protease 1, which is related to skin water content, more than lotion alone.
The present findings suggest that lotion with the FF film initiates restoration of epidermal homeostasis, leading to early improvement of dry skin.
皮肤干燥是一个普遍的皮肤问题，常伴有瘙痒，但保湿剂尚未完全解决这一问题。我们发现，我们开发的保湿剂（乳液）与超细纤维（FF）超薄薄膜的组合能早期改善皮肤干燥，但皮肤内的生物学机制仍不清楚。
8名受试者（研究1）和7名受试者（研究2）在小腿上使用含和不含FF薄膜的乳液。除了测量皮肤视觉干燥评分和电导率外，研究1在基线和治疗14天后对角质层（SC）样本进行蛋白质组分析，研究2在治疗3或5天后对皮肤活检样本进行免疫组织化学染色。
与单独使用乳液相比，乳液与FF薄膜一起使用时，皮肤干燥评分和电导率改善得更多。与表皮分化和屏障功能相关的基底层上蛋白的表达水平在颗粒层附近几天内增加，14天后在角质层中也增加。使用SC样本的蛋白质组分析表明，乳液联合FF薄膜处理降低了皮肤干燥标志物膜联蛋白A2，而与皮肤含水量相关的逆转录病毒样天冬氨酸蛋白酶1的增加幅度大于单独使用乳液。
目前的研究结果表明，含FF薄膜的乳液可启动表皮内稳态的恢复，从而早期改善皮肤干燥。
