Biological Science Research, Kao Corporation, Odawara, Japan.
Skin Care Products Research, Kao Corporation, Sumida, Japan.
Skin Res Technol. 2022 May;28(3):465-471. doi: 10.1111/srt.13149. Epub 2022 Apr 12.
Dry skin can trigger eczema that affects >10% of the US population. Dressing films have been developed to improve diseased skin, but there is limited knowledge about their effects, especially for dry skin-related symptoms. We developed an electrospinning method that creates a coating film, called a fine fiber (FF) film, characterized by the production of a transparent, thin, flexible, and adherent membrane on the skin surface.
The aim of this pilot study was to examine the effects of the FF film on dry skin.
Three treatments (lotion only, lotion with the FF film, and lotion with an alternative film) were designed to treat subjects with rough skin on their lower legs. Twenty-four females were enrolled and used either a water-based lotion U or a petrolatum-based lotion P and the FF film for 2 weeks followed by a regression phase for 1 week. Skin hydration and roughness scores were assessed as were the subjects' perceptions of the effects.
When the FF film was applied with lotion U, skin hydration was significantly improved even after 1 week, accompanied by a significant improvement of skin roughness and an increase in skin hydration by the end of the regression phase. An evaluation of moisture permeability suggested that the FF film, especially with lotion U, performed as a semipermeable membrane with optimal moisture healing effects on dry skin.
The FF film together with a water-based lotion is a promising treatment to quickly improve dry skin conditions.
干燥的皮肤会引发影响超过 10%的美国人口的湿疹。已经开发出了一些敷膜来改善患病皮肤，但对于其效果，尤其是与干燥皮肤相关的症状，人们知之甚少。我们开发了一种静电纺丝方法，可以制造出一种涂覆膜，称为细纤维（FF）膜，其特点是在皮肤表面产生透明、薄、灵活且附着力强的薄膜。
本初步研究旨在探讨 FF 膜对干燥皮肤的影响。
设计了三种处理方法（仅用乳液、用 FF 膜和用替代膜与乳液一起）来治疗小腿粗糙的受试者。共招募了 24 名女性，她们使用基于水的乳液 U 或基于凡士林的乳液 P 和 FF 膜，持续 2 周，然后是 1 周的回归期。评估了皮肤水分和粗糙度评分，以及受试者对效果的感知。
当 FF 膜与乳液 U 一起使用时，即使在第 1 周，皮肤水分也明显改善，皮肤粗糙度也显著改善，在回归期结束时皮肤水分增加。对水分渗透率的评估表明，FF 膜，特别是与乳液 U 一起使用时，表现为一种半透性膜，对干燥皮肤具有最佳的保湿愈合效果。
FF 膜与水基乳液联合使用是一种有前途的治疗方法，可以迅速改善干燥皮肤状况。
