Russell Neal, Hatcher James, Best Tim, Breuer Judith, Charlesworth James, Muir Peter, Vipond Barry, Paulus Stephane, Saxena Rohit, Simmonds Jacob, Vergnano Stefania, Davis Peter, Kadambari Seilesh
Department of Paediatric Infectious Diseases, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Department of Microbiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Open Forum Infect Dis. 2025 Apr 11;12(5):ofaf224. doi: 10.1093/ofid/ofaf224. eCollection 2025 May.
This study describes a cluster of severe parvovirus B19-associated myocarditis cases in children across England in the context of an increase in circulating virus. Cases were identified across 3 large children's centers. Eight cases presented from 1 January 2019 to 31 December 2023 as compared with 19 from 1 January 2024 to 31 August 2024. Almost all (n = 25, 93%) required intensive care, and 24 (88%) received inotropes and 4 (15%) extracorporeal membrane oxygenation. Myocarditis appears to be temporally associated and a late sequela of parvovirus B19, resulting in high rates of intensive care unit admission. Testing with serology and blood polymerase chain reaction should be part of a syndromic screen for all children with severe myocarditis.
本研究描述了在英格兰儿童中，随着循环病毒增加，出现的一组与B19细小病毒相关的严重心肌炎病例。这些病例是在3个大型儿童中心发现的。2019年1月1日至2023年12月31日有8例病例，而2024年1月1日至2024年8月31日有19例。几乎所有病例（n = 25，93%）都需要重症监护，24例（88%）接受了强心药物治疗，4例（15%）接受了体外膜肺氧合治疗。心肌炎似乎与B19细小病毒在时间上相关，是其晚期后遗症，导致重症监护病房入院率很高。血清学检测和血液聚合酶链反应检测应作为所有重症心肌炎儿童综合征筛查的一部分。
