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饮食对肠道微生物群及神经健康影响的分子视角:探索肠-脑轴

Molecular Perspective of Dietary Influences on the Gut Microbiome alongside Neurological Health: Exploring the Gut-Brain Axis.

作者信息

Almahal Zahra H, Hasan Anwarul, Razzak Shaikh Abdur, Nzila Alexis, Uddin Shihab

机构信息

Department of Bioengineering, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia.

Department of Mechanical and Industrial Engineering, Qatar University, Doha 2713, Qatar.

出版信息

ACS Chem Neurosci. 2025 Jun 4;16(11):1996-2012. doi: 10.1021/acschemneuro.5c00058. Epub 2025 May 5.

Abstract

Gut-brain axis, an intricate, two-way communication network between gut microorganisms and the central nervous system, plays a critical role in controlling brain function and thereby influencing mental health. Changes to this axis, frequently due to shifts in gut microbiota, can greatly affect brain function by hindering the creation of essential metabolites. This review examines new nutritional trends, including fermented foods and diets rich in prebiotics, that demonstrate the potential to improve microbial diversity and metabolic well-being. Although current studies emphasize possible advantages, most concentrate mainly on older populations, leaving research in younger groups limited. The field of nutritional psychiatry encounters difficulties due to the diversity in research methodologies and the intricacies of nutrient balance, potentially hindering prompt interventions. This review highlights the necessity for prolonged research to evaluate the effects of eating habits, especially regarding Western dietary patterns. Promising fields include the influence of the Mediterranean diet, the role of symbiotic and short-chain fatty acids (SCFAs), and the importance of high-fiber foods, polyphenols, and fruits and vegetables in enhancing mental health through gut-derived metabolites. We promote interdisciplinary methods that combine nutrition science, microbiology, and neurology to create tailored dietary recommendations focused on enhancing brain health.

摘要

肠-脑轴是肠道微生物群与中枢神经系统之间复杂的双向通信网络,在控制大脑功能进而影响心理健康方面起着关键作用。该轴的变化,通常是由于肠道微生物群的改变,会通过阻碍必需代谢物的产生而极大地影响大脑功能。本综述探讨了新的营养趋势,包括发酵食品和富含益生元的饮食,这些都显示出改善微生物多样性和代谢健康的潜力。尽管目前的研究强调了可能的益处,但大多数研究主要集中在老年人群体,针对年轻群体的研究有限。营养精神病学领域因研究方法的多样性和营养平衡的复杂性而面临困难,这可能会阻碍及时的干预措施。本综述强调了长期研究的必要性,以评估饮食习惯的影响,特别是西方饮食模式的影响。有前景的领域包括地中海饮食的影响、共生菌和短链脂肪酸(SCFAs)的作用,以及高纤维食物、多酚类物质以及水果和蔬菜通过肠道衍生代谢物促进心理健康的重要性。我们提倡跨学科方法,将营养科学、微生物学和神经学结合起来,制定以增强大脑健康为重点的个性化饮食建议。

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