Khan Sohail, Mathur Ashwani, Khan Fazlurrahman
Department of Biotechnology, Jaypee Institute of Information Technology, Noida, Uttar Pradesh, India.
Ocean and Fisheries Development International Cooperation Institute, Pukyong National University, Busan, Republic of Korea.
Crit Rev Microbiol. 2025 May 5:1-23. doi: 10.1080/1040841X.2025.2497795.
The growing demand for nanomedicine and its potentially diverse biological function required the investigation of raw materials for fabricating the nanomaterial. Current developments have emphasized the implementation of green chemistry to develop metal-oxide and metal nanoparticles. Endophytic fungi have emerged as a potential reservoir of bioactive compounds exemplified by unique structures and influential antibacterial properties. Over the past decade, substantial progress has been achieved in uncovering and profiling these valuable antibacterial compounds. These endophytic fungi-derived bioactive chemicals have diverse applications in various biological properties. Nanoparticle synthesis from materials derived from endophytic fungi, be it whole extracts or pure components, owing to their accessibility, cost-effectiveness in fabrication, material-tissue compatibility, and modest cytotoxicity toward higher organism cells. Nanoparticles from endophytic fungi have been utilized to treat various diseases, including those caused by bacterial, viral, and fungal pathogens. The present review provides a comprehensive discussion of the mechanistic insight into the synthesis and application of endophytic fungi-bioinspired nanoparticles as potential therapeutic agents to control microbial infection. The underlying action mechanism involved in the antimicrobial action of the nanoparticles has also been discussed. The discussion highlights various attributes of nanoparticles that may significantly benefit future researchers as potential therapeutic agents to control microbial infection.
对纳米医学不断增长的需求及其潜在的多种生物学功能，要求对用于制造纳米材料的原材料进行研究。当前的发展强调实施绿色化学来开发金属氧化物和金属纳米颗粒。内生真菌已成为生物活性化合物的潜在来源，其具有独特的结构和显著的抗菌特性。在过去十年中，在发现和分析这些有价值的抗菌化合物方面取得了重大进展。这些源自内生真菌的生物活性化学物质在各种生物学特性中具有多种应用。由内生真菌衍生材料合成纳米颗粒，无论是全提取物还是纯成分，因其易于获取、制造具有成本效益、材料与组织的相容性以及对高等生物细胞的细胞毒性较小。源自内生真菌的纳米颗粒已被用于治疗各种疾病，包括由细菌、病毒和真菌病原体引起的疾病。本综述全面讨论了对内生真菌启发的纳米颗粒作为控制微生物感染的潜在治疗剂的合成和应用的机理洞察。还讨论了纳米颗粒抗菌作用所涉及的潜在作用机制。该讨论突出了纳米颗粒的各种特性，这些特性可能会使未来的研究人员作为控制微生物感染的潜在治疗剂受益匪浅。
