尿结石中的基质糖胺聚糖

Matrix glycosaminoglycan in urinary stones.

作者信息

Nishio S, Abe Y, Wakatsuki A, Iwata H, Ochi K, Takeuchi M, Matsumoto A

出版信息

J Urol. 1985 Sep;134(3):503-5. doi: 10.1016/s0022-5347(17)47259-4.

Abstract

At first, urinary stones were classified according to their inorganic components (apatite, struvite, calcium oxalate monohydrate, calcium oxalate dihydrate and uric acid). Then, matrix glycosaminoglycan was extracted from the stones in each group and was analyzed by 2-dimensional electrophoresis. There were differences in the glycosaminoglycan content of matrices among different groups of urinary stones. The principal matrix glycosaminoglycan content consisted of hyaluronic acid in apatite and struvite stones, heparan sulfate in calcium oxalate monohydrate and uric acid stones, and hyaluronic acid and heparan sulfate in calcium oxalate dihydrate stones. We conclude that hyaluronic acid and/or heparan sulfate has an important role in urinary stone formation.

摘要

起初，尿路结石是根据其无机成分（磷灰石、鸟粪石、一水合草酸钙、二水合草酸钙和尿酸）进行分类的。然后，从每组结石中提取基质糖胺聚糖，并通过二维电泳进行分析。不同组尿路结石的基质中糖胺聚糖含量存在差异。主要的基质糖胺聚糖含量在磷灰石和鸟粪石结石中为透明质酸，在一水合草酸钙和尿酸结石中为硫酸乙酰肝素，在二水合草酸钙结石中为透明质酸和硫酸乙酰肝素。我们得出结论，透明质酸和/或硫酸乙酰肝素在尿路结石形成中起重要作用。