Horii T, Kitamura K, Ikeda M, Shiota M, Teshima K, Noda K
Jpn J Antibiot. 1985 Apr;38(4):995-1000.
The findings from fundamental and clinical studies on cefpimizole (AC-1370) in the treatment of infections in obstetrics and gynecology are reported. We investigated the transfer of AC-1370 into female genital tissues of 6 patients and the transfer of the drug into the pelvic dead space exudate in 9 patients by means of determining its concentrations in the tissues 90 to 210 minutes after the end of intravenous drip infusion of the drug over 1 hour. The mean concentration was 13.06 micrograms/g for the oviduct, 16.50 micrograms/g for the ovary, 16.50 micrograms/g for the endometrium, 14.92 micrograms/g for the myometrium, 16.58 micrograms/g for the uterine cervix, 17.75 micrograms/g for the portio vaginalis, 10.46 micrograms/ml for the uterine arterial serum and 9.91 micrograms/ml for the antecubital venous serum. The drug proved to be well transferred into the pelvic dead space exudate; it reached a peak of mean 2 hours after the end of the intravenous drip infusion of the drug over 1 hour, then decreased steadily, and was found to be a mean of 16.7 micrograms/ml even 8 hours after the end of the intravenous drip infusion. Four patients with infections in obstetrics and gynecology were then treated with AC-1370. Three out of the 4 patients responded to the treatment, while the response of another patient was unknown. None of the 4 patients showed any side effects of the drug or any abnormalities in laboratory findings.
报告了头孢咪唑（AC - 1370）治疗妇产科感染的基础研究和临床研究结果。我们通过测定在1小时静脉滴注药物结束后90至210分钟时组织中的浓度，研究了6例患者中AC - 1370向女性生殖组织的转移情况以及9例患者中药物向盆腔死腔渗出液的转移情况。输卵管的平均浓度为13.06微克/克，卵巢为16.50微克/克，子宫内膜为16.50微克/克，子宫肌层为14.92微克/克，子宫颈为16.58微克/克，阴道部为17.75微克/克，子宫动脉血清为10.46微克/毫升，肘前静脉血清为9.91微克/毫升。结果证明该药物能很好地转移至盆腔死腔渗出液中；在1小时静脉滴注药物结束后，其平均浓度在2小时达到峰值，然后稳步下降，甚至在静脉滴注结束8小时后平均仍为16.7微克/毫升。随后，4例妇产科感染患者接受了AC - 1370治疗。4例患者中有3例对治疗有反应，另1例患者的反应未知。4例患者均未出现该药物的任何副作用，实验室检查结果也均未出现异常。
