Ito K, Matsunami K, Hayasaki M, Noda K, Baba Y, Kondo H
Jpn J Antibiot. 1985 Apr;38(4):972-81.
Cefpimizole (AC-1370) concentrations in the pelvic dead space exudate were determined in patients under-going curative resection of carcinoma of the uterine cervix to study the transfer of the drug into the female genital organs, and the results were statistically analyzed, using the two-compartment model. When 1 g of AC-1370 was administered by intravenous drip infusion over 1 hour, the AC-1370 concentration in the serum from the antecubital vein reached a level of 129.09 micrograms/ml at 1 hour of intravenous drip infusion, and the AC-1370 concentration in the pelvic dead space exudate reached a peak of 30.32 micrograms/ml at 2.51 hours of intravenous drip infusion, and remained at not less than 12 micrograms/ml 8 hours after the beginning of the drip infusion, with the area under the curve (AUC) for the AC-1370 concentration in the pelvic dead space exudate being 213.66 micrograms X hr/ml. Seven patients with obstetrical and gynecological infections were treated with 1 g of AC-1370 by intravenous drip infusion over 1 hour, 2 approximately 3 times daily. Although the patients all had rather mild infections, the treatment was effective in all of them. The findings in this study proved a dose of 1 g of AC-1370 at a time to be sufficiently effective in mild cases, but in view of the transfer of the drug into tissues, it seemed necessary to administer 2 g of the drug at a time in severe cases.
为研究头孢咪唑（AC - 1370）向女性生殖器官的转移情况，对接受子宫颈癌根治性切除术的患者盆腔死腔渗出液中的头孢咪唑浓度进行了测定，并采用二室模型对结果进行了统计分析。当以静脉滴注方式在1小时内给予1g AC - 1370时，肘前静脉血清中的AC - 1370浓度在静脉滴注1小时时达到129.09微克/毫升，盆腔死腔渗出液中的AC - 1370浓度在静脉滴注2.51小时时达到峰值30.32微克/毫升，并在滴注开始8小时后保持不低于12微克/毫升，盆腔死腔渗出液中AC - 1370浓度的曲线下面积（AUC）为213.66微克·小时/毫升。7例妇产科感染患者以静脉滴注方式在1小时内给予1g AC - 1370，每天约2至3次。尽管患者的感染均较为轻微，但治疗对所有患者均有效。本研究结果证明，1g AC - 1370一次给药对轻症病例足够有效，但鉴于药物向组织的转移情况，对于重症病例似乎有必要一次给予2g药物。
