Yamamoto K, Uchida K, Eguchi F, Shirakawa K
Jpn J Antibiot. 1985 Apr;38(4):1011-6.
Cefpimizole (AC-1370), a new cephem antibiotic, was studied in the field of obstetrics and gynecology, fundamentally and clinically. And the following results were obtained. The concentrations of the drug in uterine arterial and cubital venous blood, and internal genital organs following intravenous drip infusion were measured. The results demonstrated favourable transfer of the drug into the various internal genital organs. Four patients with obstetric and gynecological infections were treated with AC-1370. The therapeutic results were good in 3, and poor in 1 case, therefore the effective rate was 75%. No side effects were noted in any cases, but the severe eosinophilia (37%) was found in 1 patient. It is therefore presumed that AC-1370 is a useful drug for infectious diseases in the field of obstetrics and gynecology.
头孢咪唑（AC - 1370）是一种新型头孢菌素类抗生素，对其进行了妇产科领域的基础和临床研究。并获得了以下结果。测定了静脉滴注后子宫动脉血、肘静脉血及内生殖器中该药物的浓度。结果表明该药物能良好地转运至各种内生殖器。4例妇产科感染患者接受了AC - 1370治疗。3例治疗效果良好，1例效果不佳，有效率为75%。所有病例均未观察到副作用，但1例患者出现严重嗜酸性粒细胞增多（37%）。因此推测AC - 1370是妇产科领域治疗传染病的一种有用药物。
