Yamamoto T, Yasuda J, Tomioka M, Kanao M, Okada H
Jpn J Antibiot. 1985 Apr;38(4):987-94.
Fundamental and clinical studies on cefpimizole (AC-1370), a new cephem antibiotic, were performed and the following results were obtained: Concentration of AC-1370 was examined in serum, internal genital organs and retroperitoneal fluid after single intravenous administration of 2.0 g dose. The venous serum level of AC-1370 was 243 micrograms/ml at 30 minutes after the administration. The sufficient transfer of AC-1370 to internal genital organs and retroperitoneal fluid was recognized. In clinical trial, AC-1370 was given to 10 cases with obstetrical and gynecological infections. The efficacy was evaluated as good in 8 cases and poor in 2 cases. No side effects were observed in any of the cases treated with AC-1370.
对新型头孢烯抗生素头孢咪唑（AC - 1370）进行了基础和临床研究，获得了以下结果：单次静脉注射2.0 g剂量后，检测了血清、内生殖器和腹膜后液中AC - 1370的浓度。给药后30分钟，AC - 1370的静脉血清水平为243微克/毫升。确认AC - 1370能充分转移至内生殖器和腹膜后液。在临床试验中，对10例妇产科感染患者给予AC - 1370。8例疗效评估为良好，2例疗效评估为不佳。接受AC - 1370治疗的任何病例均未观察到副作用。
