Opium Addiction and Coagulation Factors in ST-Segment Elevation Myocardial Infarction (STEMI) Patients: Implications for Thrombosis and Cardiovascular Outcomes.

BACKGROUND

Myocardial infarction (MI) is one of the most common causes of death globally. Since a comprehensive study on the relationship between coagulation factors in AMI patients and opium consumption has not been done, in this study the effect of opium consumption on the number of coagulation factors I, II, VII, IX, and XI in patients with myocardial infarction and ST-elevated (STEMI) was investigated. Furthermore, our results shed light on the relationship between opium and coagulation factors with thrombosis grades.

METHODS

In this case-control study, 80 STEMI patients referred to Razi Birjand Hospital, Iran, between years 2021 to 2022 were divided into two groups of opium addicts and non-addicts based on opium consumption and non-addict use, and the levels of the mentioned coagulation factors in their plasma were measured and compared with the corresponding values in 80 healthy people. Collected data was analyzed using SPSS software. The significance level of all tests was 5%.

RESULTS

The number of coagulation factors I, II, VII, and IX, unlike factor XI, in the opium addict group was significantly higher than the other two groups. While there was no statistically significant relationship between these coagulation factors with different degrees of thrombosis, most of the studied population were classified as Grade 5. Results also suggest no significant correlation between biochemical parameters and opium consumption.

CONCLUSION

Opium consumption can cause thrombosis by increasing the level of some coagulation factors. The findings from this study could have implications for clinical practice and public health interventions related to opium addiction and its impact on cardiovascular outcomes.