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维持性血液透析患者舌苔厚度与微炎症状态及口腔微生物群的相关性

Correlation of tongue coating thickness with microinflammatory state and oral microbiome in maintenance hemodialysis patients.

作者信息

Zhu Yanqin, Zeng Xueyan, Zhang Aiping, Lu Bin, Wu Mengqi, Liu Hong, Zhu Fenggui, Lin Riyang

机构信息

Department of Nephrology, Hangzhou TCM Hospital of Zhejiang Chinese Medical University, Hangzhou City, China.

Department of Nephrology, Sichuan Second Hospital of Traditional Chinese Medicine, Chengdu City, China.

出版信息

J Oral Microbiol. 2025 May 5;17(1):2488054. doi: 10.1080/20002297.2025.2488054. eCollection 2025.

DOI:10.1080/20002297.2025.2488054
PMID:40330867
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12054557/
Abstract

AIM

This study investigated the correlation between tongue coating thickness (TCT), micro-inflammatory state (MIS), and oral microbiome in maintenance hemodialysis (MHD) patients.

METHODS

Forty MHD patients (20 thin-tongue coating [BTZ], 20 thick-tongue coating [HTZ]) and 15 healthy controls (DZZ) were enrolled. Blood microinflammatory markers were analyzed in all patients. Saliva samples from 15 HTZ, 15 BTZ, and 15 DZZ underwent 16S rRNA sequencing.

RESULTS

HTZ patients exhibited higher microinflammatory marker levels than BTZ. Oral microbiome species richness in DZZ surpassed that of the MHD groups, with distinct structural differences, particularly between HTZ and DZZ. HTZ showed higher abundances of , and Lachnospiraceae than BTZ. Correlation analysis revealed a positive correlation between the levels of IL-6 and TNF-α and the abundance of , but a negative correlation with . Additionally, the TNF-α level positively correlated with .

CONCLUSION

Thick tongue coating in MHD patients is associated with elevated microinflammation and altered oral microbiome, suggesting a link between inflammation and microbial dysbiosis.

摘要

目的

本研究调查维持性血液透析（MHD）患者的舌苔厚度（TCT）、微炎症状态（MIS）与口腔微生物群之间的相关性。

方法

纳入40例MHD患者（20例薄舌苔[BTZ]，20例厚舌苔[HTZ]）和15例健康对照者（DZZ）。分析所有患者的血液微炎症标志物。对15例HTZ、15例BTZ和15例DZZ的唾液样本进行16S rRNA测序。

结果

HTZ患者的微炎症标志物水平高于BTZ。DZZ的口腔微生物群物种丰富度超过MHD组，结构存在明显差异，尤其是HTZ和DZZ之间。HTZ的 、毛螺菌科的丰度高于BTZ。相关性分析显示，IL-6和TNF-α水平与 的丰度呈正相关，但与 呈负相关。此外，TNF-α水平与 呈正相关。

结论

MHD患者的厚舌苔与微炎症升高和口腔微生物群改变有关，提示炎症与微生物失调之间存在联系。

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