Kot Karolina, Michaliszyn Adam, Kalisińska Elżbieta, Lepczyńska Małgorzata
Department of Biology and Medical Parasitology, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111, Szczecin, Poland.
Department of Medical Biology, School of Public Health, University of Warmia and Mazury, Żołnierska 14C, 10-561, Olsztyn, Poland.
Gut Pathog. 2024 Apr 3;16(1):19. doi: 10.1186/s13099-024-00613-z.
Blastocystis sp. is one of the most frequently detected protozoa during stool specimen examination. In the last decade, the studies about the pathogenic potential of Blastocystis sp. have intensified. Additionally, treatment approaches against this parasite are still disputable. The study aimed to investigate the in vitro activity of the substances of natural origin against two subtypes (ST) of Blastocystis sp.-ST3 and ST7. Garlic and turmeric extracts exhibited the highest inhibitory effect in relation to the ST3 viability. While horseradish and turmeric were found to be the most effective extracts to the ST7 viability. The study showed that ginger, garlic, horseradish, and turmeric extracts have potent antimicrobial activity against Blastocystis ST3 and ST7, with the half-maximal inhibitory concentration (IC) ranging from 3.8 to 4.8 µg/ml and from 3.3 to 72.0 µg/ml, respectively, and thus may be useful in the prevention and control of Blastocystis infections. Additionally, this research confirmed that Blastocystis ST7 is more resistant to the selected plant extracts treatment than Blastocystis ST3 which in consequence may bring some difficulties in its eradication.
芽囊原虫是粪便标本检查中最常检测到的原生动物之一。在过去十年中，关于芽囊原虫致病潜力的研究不断加强。此外，针对这种寄生虫的治疗方法仍存在争议。该研究旨在调查天然来源物质对芽囊原虫的两种亚型（ST）——ST3和ST7的体外活性。大蒜和姜黄提取物对ST3的活力表现出最高的抑制作用。而辣根和姜黄被发现是对ST7活力最有效的提取物。该研究表明，生姜、大蒜、辣根和姜黄提取物对芽囊原虫ST3和ST7具有强大的抗菌活性，半最大抑制浓度（IC）分别为3.8至4.8微克/毫升和3.3至72.0微克/毫升，因此可能有助于预防和控制芽囊原虫感染。此外，该研究证实，芽囊原虫ST7比芽囊原虫ST3对所选植物提取物治疗更具抗性，这可能会给根除它带来一些困难。
