Teichenné Joan, Tobajas Yaiza, Leonard Kevin, Tchoumtchoua Job, Escoté Xavier
Eurecat-Centre Tecnològic de Catalunya, Unitat de Nutrició i Salut, 43204 Reus, Spain.
Biomass Valorisation Platform, Extraction Department, CELABOR Srl, 4650 Herve, Belgium.
Molecules. 2025 Apr 17;30(8):1806. doi: 10.3390/molecules30081806.
Polyphenol-rich extracts derived from agricultural by-products exhibit promising antiviral properties. This study evaluated the antiviral potential of extracts from red onion peels, vineyard prunings, olive prunings and chicory leaves against human coronavirus HuCoV-229E. Subcritical water extraction and resin adsorption techniques were applied to produce the extracts. The extracts were further characterised for their bioactive content, and three out of four extracts showed a high polyphenol content (>200 mg/g). The antiviral activity was assessed through viral infectivity and replication inhibition assays in human MRC-5 host cells. The results indicate that chicory leaf and red onion peel extracts demonstrated significant antiviral effects, with effective concentrations (EC) of 61.43 µg/mL and 10.1 µg/mL, respectively. Olive pruning extract exhibited moderate activity, while vineyard pruning extract showed limited efficacy. These findings suggest that polyphenol-rich agricultural by-products could serve as sustainable sources for antiviral agents, warranting further investigation into their mechanisms of action and potential applications against other coronaviruses, including SARS-CoV-2.
源自农业副产品的富含多酚的提取物具有良好的抗病毒特性。本研究评估了红洋葱皮、葡萄园修剪枝条、橄榄修剪枝条和菊苣叶提取物对人冠状病毒HuCoV-229E的抗病毒潜力。采用亚临界水萃取和树脂吸附技术制备提取物。对提取物的生物活性成分进行了进一步表征，四种提取物中有三种显示出高多酚含量（>200 mg/g）。通过在人MRC-5宿主细胞中的病毒感染性和复制抑制试验评估抗病毒活性。结果表明，菊苣叶和红洋葱皮提取物表现出显著的抗病毒作用，有效浓度（EC）分别为61.43 µg/mL和10.1 µg/mL。橄榄修剪枝条提取物表现出中等活性，而葡萄园修剪枝条提取物的效果有限。这些发现表明，富含多酚的农业副产品可作为抗病毒剂的可持续来源，有必要进一步研究其作用机制以及针对包括SARS-CoV-2在内的其他冠状病毒的潜在应用。
