EGCG，一种绿茶多酚，能够抑制人冠状病毒在体外的复制。
EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro.
机构信息
Division of Biological Science and Technology, Yonsei University, Wonju, Republic of Korea.
Division of Biological Science and Technology, Yonsei University, Wonju, Republic of Korea.
出版信息
Biochem Biophys Res Commun. 2021 Apr 2;547:23-28. doi: 10.1016/j.bbrc.2021.02.016. Epub 2021 Feb 10.
COVID-19 pandemic results in record high deaths in many countries. Although a vaccine for SARS-CoV-2 is now available, effective antiviral drugs to treat coronavirus diseases are not available yet. Recently, EGCG, a green tea polyphenol, was reported to inhibit SARS-CoV-2 3CL-protease, however the effect of EGCG on coronavirus replication is unknown. In this report, human coronavirus HCoV-OC43 (beta coronavirus) and HCoV-229E (alpha coronavirus) were used to examine the effect of EGCG on coronavirus. EGCG treatment decreases 3CL-protease activity of HCoV-OC43 and HCoV-229E. Moreover, EGCG treatment decreased HCoV-OC43-induced cytotoxicity. Finally, we found that EGCG treatment decreased the levels of coronavirus RNA and protein in infected cell media. These results indicate that EGCG inhibits coronavirus replication.
新冠疫情大流行导致许多国家的死亡人数创历史新高。虽然现在有了针对 SARS-CoV-2 的疫苗，但还没有有效的抗病毒药物来治疗冠状病毒病。最近，有报道称绿茶多酚 EGCG 可抑制 SARS-CoV-2 3CL-蛋白酶，但 EGCG 对冠状病毒复制的影响尚不清楚。在本报告中，使用人冠状病毒 HCoV-OC43（β冠状病毒）和 HCoV-229E（α冠状病毒）来研究 EGCG 对冠状病毒的作用。EGCG 处理可降低 HCoV-OC43 和 HCoV-229E 的 3CL-蛋白酶活性。此外，EGCG 处理还降低了 HCoV-OC43 诱导的细胞毒性。最后，我们发现 EGCG 处理可降低感染细胞培养基中冠状病毒 RNA 和蛋白的水平。这些结果表明 EGCG 可抑制冠状病毒复制。
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