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中枢神经系统原发性类癌肿瘤:一例诊断具有挑战性的罕见病例报告

Primary Carcinoid Tumor of the Central Nervous System: A Rare Case Report with a Diagnostic Challenge.

作者信息

Singh Anurag, Singh Alka, Bhaisora Kamlesh Singh, Krishnani Narendra

机构信息

Department of Pathology, Sanjay Gandhi Post Graduate Institute of Medical Science, Lucknow, Uttar Pradesh, India.

Department of Neurosurgery, Sanjay Gandhi Post Graduate Institute of Medical Science, Lucknow, Uttar Pradesh, India.

出版信息

Int J Appl Basic Med Res. 2025 Apr-Jun;15(2):128-131. doi: 10.4103/ijabmr.ijabmr_523_24. Epub 2025 Apr 7.

Abstract

Carcinoid tumors (CTs) are slow-growing neuroendocrine neoplasms that may arise in any part of the body. They usually affect the lungs or gut. Primary intradural extramedullary CTs of the central nervous system are rare; few cases have been reported. This case report describes a 36-year-old patient with lower back discomfort, weakness, and lower leg pain for 8 months. Contrast-enhanced magnetic resonance imaging of the lumbosacral spine, from the lower L3 vertebral level to the L4-5 disc level, revealed a 4.5 cm × 2.5 cm × 1.5 cm intradural mass lesion. The main differential diagnoses were on clinical and radiographic examination: nerve sheath tumors, meningiomas, and myxopapillary ependymomas. The tumor was excised en bloc after an L3-L5 lumbar laminectomy. Histomorphology and immunohistochemistry made a definitive diagnosis of CT of the lumbar spine. Two years after surgery, there was no clinical or radiological evidence of tumor recurrence or metastasis. The present case study is intended to effectively diagnose and treat spinal intradural extramedullary CTs.

摘要

类癌肿瘤(CTs)是生长缓慢的神经内分泌肿瘤,可发生于身体的任何部位。它们通常影响肺部或肠道。中枢神经系统原发性硬脊膜内髓外类癌肿瘤罕见,仅有少数病例报道。本病例报告描述了一名36岁患者,其下背部不适、无力及小腿疼痛8个月。腰骶部脊柱的增强磁共振成像显示,从L3椎体下部至L4 - 5椎间盘水平有一个4.5 cm×2.5 cm×1.5 cm的硬脊膜内肿块病变。临床和影像学检查的主要鉴别诊断包括:神经鞘瘤、脑膜瘤和黏液乳头型室管膜瘤。在L3 - L5腰椎椎板切除术后,肿瘤被整块切除。组织形态学和免疫组化确诊为腰椎类癌肿瘤。术后两年,无肿瘤复发或转移的临床及影像学证据。本病例研究旨在有效诊断和治疗脊柱硬脊膜内髓外类癌肿瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e52/12058044/664c8a4c43d6/IJABMR-15-128-g001.jpg

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