Xu Zhao, Yin Ke, Wang Liming, Dong Lijie, Sun Jing, Liu Aihua
Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, No. 251 Fukuang Road, Nankai District, Tianjin, China.
Biomed Eng Online. 2025 May 9;24(1):56. doi: 10.1186/s12938-025-01386-5.
This observational, prospective, analytical, and cross-sectional study was designed to systematically analyze ocular biometric parameters in patients with nuclear cataract exhibiting nuclear hardness grade ≥ 3 according to the Emery-Little classification under slit-lamp examination who scheduled for phacoemulsification. Ocular biometric measurements were acquired using the IOL Master 700, a swept-source optical coherence tomography (SS-OCT) device.
Age was negatively correlated with axial length (AL), anterior chamber depth (ACD), white-to-white (WTW), and pupil diameter (PD) (r = - 0.13, r = - 0.26, r = - 0.18, all P < 0.001; r = - 0.09, P < 0.01) but positively correlated with total steep keratometry (TKs) (r = 0.13, P < 0.001). AL was negatively correlated with total flat keratometry (TKf), TKs, and WTW (r = - 0.3, r = - 0.27, r = - 0.18, all P < 0.001) but positively correlated with ACD and PD (r = 0.43, r = 0.10, all P < 0.001). Men had smaller TK and PD but larger WTW than women.
These findings highlight significant sex-related differences in biometric parameters among patients with nuclear cataract, which are closely related to AL and age. Considering variation with these parameters helps personalize surgical plans and prevent complications.
本观察性、前瞻性、分析性横断面研究旨在系统分析根据裂隙灯检查的Emery-Little分类法，核硬度等级≥3级且计划进行超声乳化手术的核性白内障患者的眼部生物测量参数。使用IOL Master 700（一种扫频光学相干断层扫描（SS-OCT）设备）获取眼部生物测量数据。
年龄与眼轴长度（AL）、前房深度（ACD）、白对白（WTW）和瞳孔直径（PD）呈负相关（r = -0.13，r = -0.26，r = -0.18，均P < 0.001；r = -0.09，P < 0.01），但与总陡峭角膜曲率（TKs）呈正相关（r = 0.13，P < 0.001）。AL与总平坦角膜曲率（TKf）、TKs和WTW呈负相关（r = -0.3，r = -0.27，r = -0.18，均P < 0.001），但与ACD和PD呈正相关（r = 0.43，r = 0.10，均P < 0.001）。男性的TK和PD较小，但WTW比女性大。
这些发现突出了核性白内障患者生物测量参数中存在显著的性别差异，这些差异与AL和年龄密切相关。考虑这些参数的变化有助于个性化手术方案并预防并发症。
