Cocchetto D M, Miller D B, Miller L L, Bjornsson T D
Physiol Behav. 1985 May;34(5):727-34. doi: 10.1016/0031-9384(85)90371-3.
Anecdotal observations of the behavior of rats with a vitamin K-deficiency suggested that this deficiency was associated with hypoactivity, general malaise, and a lack of exploratory behavior. These observations were pursued by assessing locomotor activity in a circular photocell-monitored track, open-field activity, and radial-arm maze performance in rats rendered vitamin K-deficient by dietary depletion or by warfarin treatment. There was a significant reduction (approximately 25% at the median) in the locomotor activity of dietary vitamin K-deficient rats compared with rats fed a control diet. In the open-field, warfarin administration was associated with a significant shift from more exploratory behaviors to less exploratory behaviors. Consistent with these findings, radial-arm maze assessment showed a comparative reduction in locomotor activity in the dietary vitamin K-deficient rats with no alteration in performance, i.e., short-term memory. These animal behavioral studies suggest that sub-clinical and clinical vitamin K-deficiency may contribute to physical and psychiatric symptomatology.
对维生素K缺乏大鼠行为的轶事观察表明，这种缺乏与活动减退、全身不适和缺乏探索行为有关。通过评估在圆形光电管监测跑道上的运动活动、旷场活动以及通过饮食消耗或华法林治疗导致维生素K缺乏的大鼠的放射状臂迷宫表现，来探究这些观察结果。与喂食对照饮食的大鼠相比，饮食中维生素K缺乏的大鼠的运动活动显著降低（中位数约为25%）。在旷场实验中，给予华法林与从更多探索行为向更少探索行为的显著转变有关。与这些发现一致，放射状臂迷宫评估显示，饮食中维生素K缺乏的大鼠的运动活动相对减少，而表现即短期记忆没有改变。这些动物行为研究表明，亚临床和临床维生素K缺乏可能导致身体和精神症状。
